3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(tritylamino)propanoic acid | 1228040-62-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(tritylamino)propanoic acid
• 英文别名: (2S)-3-(5-chloro-2,4-dioxopyrimidin-1-yl)-2-(tritylamino)propanoic acid
• CAS: 1228040-62-7
• 化学式: C₂₆H₂₂ClN₃O₄
• 分子量: 475.931
• InChiKey: FWPQOUBFYSOOFH-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  98.7
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(tritylamino)propanoate 在 水 、 sodium hydroxide 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 20.0h， 生成 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(tritylamino)propanoic acid
  参考文献：
  名称：

  Synthesis of Acyclic Nucleosides with a Chiral Amino Side Chain by the Mitsunobu Coupling Reaction

  摘要：

  A novel and efficient synthetic method has been developed Oar the preparation of chiral acyclic nucleosides with a chiral amino side chain by Mitsunobu reaction between nucleoside bases and protected L-serine. This method suggests a potentially more efficient and complementary process to acquire chiral acyclic nucleosides.

  DOI：

  10.1021/jo100397a

文献信息

• Synthesis of Acyclic Nucleosides with a Chiral Amino Side Chain by the Mitsunobu Coupling Reaction
  作者：Hai-Ming Guo、Yan-Yan Wu、Hong-Ying Niu、Dong-Chao Wang、Gui-Rong Qu

  DOI：10.1021/jo100397a

  日期：2010.6.4

  A novel and efficient synthetic method has been developed Oar the preparation of chiral acyclic nucleosides with a chiral amino side chain by Mitsunobu reaction between nucleoside bases and protected L-serine. This method suggests a potentially more efficient and complementary process to acquire chiral acyclic nucleosides.