4-maleimido-4'-[2-(2-hydroxyethylthio)succinimido]azobenzene | 1313494-17-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: 4-maleimido-4'-[2-(2-hydroxyethylthio)succinimido]azobenzene
• CAS: 1313494-17-5
• 化学式: C₂₂H₁₈N₄O₅S
• 分子量: 450.475
• InChiKey: FEQSQJVARFPSIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.89
• 重原子数：
  32.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  119.71
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  4-maleimido-4'-[2-(2-hydroxyethylthio)succinimido]azobenzene 以 二甲基亚砜 为溶剂， 生成 4-maleimido-4'-[2-(2-hydroxyethylthio)succinimido]azobenzene
  参考文献：
  名称：

  New azobenzene derivatives for directed modification of proteins

  摘要：

  Derivatives of azobenzene which contained a maleimide group in one of the benzene rings (for binding to a protein cysteine residue) and maleimide, hydroxyl, or carboxyl substitutes in another benzene ring were synthesized. The reactivity of these compounds towards a cysteine residue of a protein and their optical properties in a free form and after their attachment to the mutant forms of the SsoII restriction endonuclease were studied.

  DOI：

  10.1134/s1068162009050033
• 作为产物：
  描述：

  4,4'-双（马来酰氨基）偶氮苯 、 2-巯基乙醇 以 1,4-二氧六环 为溶剂， 以25%的产率得到4-maleimido-4'-[2-(2-hydroxyethylthio)succinimido]azobenzene
  参考文献：
  名称：

  New azobenzene derivatives for directed modification of proteins

  摘要：

  Derivatives of azobenzene which contained a maleimide group in one of the benzene rings (for binding to a protein cysteine residue) and maleimide, hydroxyl, or carboxyl substitutes in another benzene ring were synthesized. The reactivity of these compounds towards a cysteine residue of a protein and their optical properties in a free form and after their attachment to the mutant forms of the SsoII restriction endonuclease were studied.

  DOI：

  10.1134/s1068162009050033