(5E,9E)-13-chloro-14,16-bis(ethoxymethoxy)-11-((2-oxo-2-(piperidin-1-yl)ethoxy)imino)-3,4,7,8,11,12-hexahydro-1H-benzo[c][1]oxacyclotetradecin-1-one | 1183860-63-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (5E,9E)-13-chloro-14,16-bis(ethoxymethoxy)-11-((2-oxo-2-(piperidin-1-yl)ethoxy)imino)-3,4,7,8,11,12-hexahydro-1H-benzo[c][1]oxacyclotetradecin-1-one
• CAS: 1183860-63-0
• 化学式: C₃₀H₄₁ClN₂O₈
• 分子量: 593.117
• InChiKey: IRTIBDLOSAHFSC-ZYSWSLPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.47
• 重原子数：
  41.0
• 可旋转键数：
  11.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  105.12
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  (5E,9E)-13-chloro-14,16-bis(ethoxymethoxy)-11-((2-oxo-2-(piperidin-1-yl)ethoxy)imino)-3,4,7,8,11,12-hexahydro-1H-benzo[c][1]oxacyclotetradecin-1-one 在 polystyrene-sulfonic acid 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 Pochoxime A 、 NXD30002
  参考文献：
  名称：

  针对 HSP90 的 Pochonin 文库的不同合成和已鉴定抑制剂的体内功效。

  摘要：

  The heat shock protein 90 (HSP90) has emerged as one of the most exciting therapeutic target in recent years.[1, 2] Despite the seemingly ubiquitous function of this constitutively expressed chaperone, its role in stabilizing conformationally labile proteins has implications in pathologies ranging from oncology to neurodegenerative diseases. Most of HSP90’s endogenous clients[3] are key regulators of cell signaling which are destabilized and degraded in the absence of HSP90’s chaperoning activity. The dependence of transformed cells on HSP90 is further heightened by the fact that many oncogenic mutations, while increasing the activity of pro-growth signaling pathways, are less stable than their wild type counterpart and have an increased dependence on HSP90’s chaperoning activity.[4] A clinically relevant example is the heightened dependence of drug resistant Bcr-Abl mutants on HSP90’s activity and the fact that HSP90 inhibitors in combination with Abl inhibitors remain effective against such mutants.[5, 6] Accordingly, HSP90 inhibition provides a broad and effective target for anticancer treatment. Furthermore, HSP90 inhibitors can act synergistically with a cytotoxic agent.[7] HSP90 is also implicated in regulating the fate of a number of conformationally unstable proteins which underlie the development of neurodegenerative diseases.[8] It has been shown that HSP90 inhibitors can reduce protein aggregates in cellular and animal models of Huntington disease,[9] spinal and bulbar muscular atrophy,[10] Parkinson disease,[11] and other Tau protein-related neurodegenerative diseases.[12]

  DOI：

  10.1002/anie.200800233
• 作为产物：
  描述：

  在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 甲苯 为溶剂， 以60%的产率得到(5E,9E)-13-chloro-14,16-bis(ethoxymethoxy)-11-((2-oxo-2-(piperidin-1-yl)ethoxy)imino)-3,4,7,8,11,12-hexahydro-1H-benzo[c][1]oxacyclotetradecin-1-one
  参考文献：
  名称：

  Synthesis of pochoxime prodrugs as potent HSP90 inhibitors

  摘要：

  Pochoximes are potent inhibitors of heat shock protein 90 (HSP90) based on the radicicol pharmacophores. Herein we present a pharmacokinetics and pharmacodynamics evaluation of this compound series as well as a phosphate prodrug strategy to facilitate formulation and improve oral bioavailability. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.030