2-methyl-6-phenyl-5-(4-{4-[5-(4-trifluoromethyl-pyridin-2-yl)-1H-[1,2,4]triazol-3-yl]-piperidin-1-ylmethyl}-phenyl)-[1,2,4]triazolo[1,5-a]pyrimidine | 1240468-23-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-methyl-6-phenyl-5-(4-{4-[5-(4-trifluoromethyl-pyridin-2-yl)-1H-[1,2,4]triazol-3-yl]-piperidin-1-ylmethyl}-phenyl)-[1,2,4]triazolo[1,5-a]pyrimidine
• 英文别名: 2-methyl-6-phenyl-5-[4-[[4-[3-[4-(trifluoromethyl)pyridin-2-yl]-1H-1,2,4-triazol-5-yl]piperidin-1-yl]methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyrimidine
• CAS: 1240468-23-8
• 化学式: C₃₂H₂₈F₃N₉
• 分子量: 595.63
• InChiKey: NYHLUFKJUFABOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  44
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• FUSED PYRIMIDINES
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP2396330A1

  公开（公告）日：2011-12-21
• US8957064B2
  申请人：——

  公开号：US8957064B2

  公开（公告）日：2015-02-17
• [EN] FUSED PYRIMIDINES<br/>[FR] PYRIMIDINES CONDENSÉES
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2010091808A1

  公开（公告）日：2010-08-19

  Compounds of formula (I), or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6, R7, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.