4-(1-methyl-3-azabicyclo[3.1.0]hex-3-yl)-2-butynol | 659736-74-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(1-methyl-3-azabicyclo[3.1.0]hex-3-yl)-2-butynol
• 英文别名: 4-(1-Methyl-3-azabicyclo[3.1.0]hex-3-yl)-2-butyn-1-ol；4-(1-methyl-3-azabicyclo[3.1.0]hexan-3-yl)but-2-yn-1-ol
• CAS: 659736-74-0
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: OJDWUJOKIQJPTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] 3,6-DISUBSTITUTED AZABICYCLO [3.1.0]HEXANE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS<br/>[FR] DERIVES 3,6-DISUBSTITUES D'AZABICYCLO [3.1.0]HEXANE UTILISES COMME ANTAGONISTES DES RECEPTEURS MUSCARINIQUES
  申请人：RANBAXY LAB LTD

  公开号：WO2004014853A1

  公开（公告）日：2004-02-19

  This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0]hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.

  这项发明通常涉及3,6-二取代的氮杂双环[3.1.0]己烷衍生物。本发明的化合物是肌碱受体拮抗剂，可用于治疗通过肌碱受体介导的呼吸系统、泌尿系统和消化系统的各种疾病。该发明还涉及一种制备本发明化合物的方法，含有本发明化合物的药物组合物以及治疗通过肌碱受体介导的疾病的方法。
• 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
  申请人：Mehta Anita

  公开号：US20060122253A1

  公开（公告）日：2006-06-08

  This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0]hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.

  本发明一般涉及3,6-二取代的氮杂双环[3.1.0]己烷衍生物。本发明的化合物是肌肉型乙酰胆碱受体拮抗剂，可用于治疗通过肌肉型乙酰胆碱受体介导的呼吸、泌尿和胃肠系统的各种疾病。本发明还涉及一种制备本发明化合物的方法，含有本发明化合物的制药组合物以及治疗通过肌肉型乙酰胆碱受体介导的疾病的方法。
• EP1546098A4
  申请人：——

  公开号：EP1546098A4

  公开（公告）日：2006-08-23
• 3,6-DISUBSTITUTED AZABICYCLO [3.1.0]HEXANE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS
  申请人：Ranbaxy Laboratories Limited

  公开号：EP1546098A1

  公开（公告）日：2005-06-29
• US7265147B2
  申请人：——

  公开号：US7265147B2

  公开（公告）日：2007-09-04