{2-[(3-methoxyphenyl)amino]-1,3-thiazol-4-yl}(4-methylpiperidin-1-yl)methanone | 1366233-79-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: {2-[(3-methoxyphenyl)amino]-1,3-thiazol-4-yl}(4-methylpiperidin-1-yl)methanone
• 英文别名: [2-(3-Methoxyanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
• CAS: 1366233-79-5
• 化学式: C₁₇H₂₁N₃O₂S
• 分子量: 331.439
• InChiKey: CCXFZPWDWFBOBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  82.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] COMPOUNDS<br/>[FR] COMPOSÉS
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2012037351A1

  公开（公告）日：2012-03-22

  Compounds, pharmaceutical compositions containing them, and their use treatment of conditions mediated by the TRPC3 and/or TRPC6 ion channels.

  化合物，含有它们的制药组合物，以及它们用于治疗由TRPC3和/或TRPC6离子通道介导的疾病的用途。
• Preparation of a conjugated molecule and materials for use therein
  申请人：Spivey Christopher Alan

  公开号：US20050165185A1

  公开（公告）日：2005-07-28

  A method for preparing a conjugated molecule comprising a first monomer coupled to a second monomer, said method comprising: (i) linking the first monomer to a solid support via the germanium atom of a germyl linking group; (ii) coupling the first monomer to the second monomer in a coupling position to form a bound conjugated molecule, wherein the second monomer has a protecting group in a non-coupling position; (iii) optionally sequentially coupling a third, fourth . . . and n th monomer to the second, third and (n−1) th monomer respectively; (iv) removing the protecting group; and (v) ipso-degermylation to release the bound conjugated molecule.

  一种制备共轭分子的方法，包括将第一单体通过锗链连接基固定在固体支撑上；在偶联位置上将第一单体与第二单体耦合形成结合的共轭分子，其中第二单体在非偶联位置上具有保护基；可选地，依次将第三、第四……第n个单体耦合到第二、第三和（n-1）个单体上；去除保护基；并进行ipso-脱锗以释放结合的共轭分子。
• UNIQUE HALOGEN-INDUCED CYCLIZATIONS, REAGENTS THEREFOR, AND COMPOUNDS PRODUCED THEREBY
  申请人：Snyder Scott Alan

  公开号：US20140243404A1

  公开（公告）日：2014-08-28

  This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed. A representative halonium compound of the disclosure is:

  本披露涉及有用于多烯环化、烯酸和烯基烷醚环化以及芳香族化合物卤代的卤化物化合物。披露了这种卤化物化合物的合成、使用这种卤化物化合物制备的化合物以及使用卤化物化合物合成天然化合物，包括蒎烯。本披露的代表性卤化物化合物为：
• Reagents methodsand kits for use in deactivating nucleic acids
  申请人：Gen-Probe Incorporated

  公开号：EP2286845A1

  公开（公告）日：2011-02-23

  A formulation for use in preventing nucleic acids from acting as templates in an amplification reaction when the solution is combined with a nucleic acid deactivating agent, the formulation comprising a corrosion-inhibiting agent, a wetting agent, and a solubilizing agent, wherein each of said agents remains substantially in solution at 22°C, and wherein each agent is present in an amount that when the formulation is combined with an amount of a deactivating agent sufficient for the combined formulation to substantially deactivate nucleic acids, the corrosion-inhibiting agent reduces the corrosive properties of the deactivating agent, the wetting agent improves the dispersion properties of the deactivating agent on a solid surface and/or increases the solubility of the deactivating agent and/or other material that may be present on a solid surface or in a formulation, and the solubilizing agent increases the solubility of at least one of the deactivating agent, the corrosion-inhibiting agent, and the wetting agent.

  一种用于防止核酸在扩增反应中用作模板的制剂，当溶液与核酸失活剂结合时，该制剂包括腐蚀抑制剂、润湿剂和增溶剂，其中每种所述制剂在 22°C 时基本上保持在溶液中，并且每种制剂的存在量当该制剂与一定量的失活剂结合时足以使结合后的制剂基本上使核酸失活、缓蚀剂降低失活剂的腐蚀性，润湿剂改善失活剂在固体表面的分散性和/或增加失活剂和/或可能存在于固体表面或制剂中的其他材料的溶解性，增溶剂增加失活剂、缓蚀剂和润湿剂中至少一种的溶解性。
• Reagents, methods and kits for use in deactivating nucleic acids
  申请人：Nelson C. Norman

  公开号：US20050202491A1

  公开（公告）日：2005-09-15

  The present invention relates to reagents for use in deactivating nucleic acids and methods of making and using the same.

  本发明涉及用于使核酸失活的试剂及其制造和使用方法。