6-ethyl-1-(4-chloro-phenyl)-6-methyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine; hydrochloride | 108483-27-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 6-ethyl-1-(4-chloro-phenyl)-6-methyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine; hydrochloride
• 英文别名: 6-Aethyl-1-(4-chlor-phenyl)-6-methyl-1,6-dihydro-[1,3,5]triazin-2,4-diyldiamin; Hydrochlorid；1-(4-Chlorophenyl)-6-ethyl-6-methyl-1,3,5-triazine-2,4-diamine;hydrochloride
• CAS: 108483-27-8
• 化学式: C₁₂H₁₆ClN₅*ClH
• 分子量: 302.206
• InChiKey: ZIKQBFVZCWTFDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.34
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  80
• 氢给体数：
  3
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  对氯苯胺 、 二聚氰胺 、 丁酮 在 盐酸 作用下， 以68%的产率得到6-ethyl-1-(4-chloro-phenyl)-6-methyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine; hydrochloride
  参考文献：
  名称：

  1-Aryl-4,6-diamino-1,2-dihydrotriazine as antimalarial agent: a new synthetic route

  摘要：

  Some novel derivatives of 1-aryl-4,6-diamino-1,2-dihydrotriazines have been synthesized using neat technology under microwaves. These were tested in vitro against both sensitive and resistant Plasmodium falciparum strains for antimalarial activity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.049

文献信息

• 1-Aryl-4,6-diamino-1,2-dihydrotriazine as antimalarial agent: a new synthetic route
  作者：M. Kidwai、P. Mothsra、R. Mohan、S. Biswas

  DOI：10.1016/j.bmcl.2004.12.049

  日期：2005.2

  Some novel derivatives of 1-aryl-4,6-diamino-1,2-dihydrotriazines have been synthesized using neat technology under microwaves. These were tested in vitro against both sensitive and resistant Plasmodium falciparum strains for antimalarial activity. (C) 2004 Elsevier Ltd. All rights reserved.