4-Methoxy-1-methyl-piperidon-(2) | 89895-59-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-Methoxy-1-methyl-piperidon-(2)
• 英文别名: 4-methoxy-1-methyl-piperidin-2-one；4-Methoxy-1-methylpiperidin-2-one
• CAS: 89895-59-0
• 化学式: C₇H₁₃NO₂
• 分子量: 143.186
• InChiKey: HXSAUSVZXOSPEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] 2-PYRIDINE ALKYNE DERIVATIVES USEFUL FOR TREATING PAIN<br/>[FR] DERIVES DE 2-PYRIDINE ALKYNE SERVANT AU TRAITEMENT DE LA DOULEUR
  申请人：EURO CELTIQUE SA

  公开号：WO2005007641A1

  公开（公告）日：2005-01-27

  The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson’s disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington’s chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.

  本发明提供了化合物式(I)的化合物：（其中R1，Q，A和R2在此披露）或其药学上可接受的盐（“吡啶-炔基化合物”）；包括有效量的吡啶-炔基化合物的制药组合物；以及治疗或预防动物的疼痛、尿失禁、成瘾障碍、帕金森病、帕金森综合症、焦虑、癫痫、癫痫发作、中风、瘙痒症、精神病、认知障碍、记忆缺陷、脑功能受限、亨廷顿舞蹈症、肌萎缩侧索硬化症、痴呆、视网膜病、肌肉痉挛、偏头痛、呕吐、运动障碍或抑郁症的方法，包括向需要治疗的动物中投与有效量的吡啶-炔基化合物。
• [EN] SOS1 PROTEOLYSIS MODULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF<br/>[FR] MODULATEUR DE PROTÉOLYSE SOS1, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION<br/>[ZH] SOS1蛋白水解调节剂及其制备方法和应用
  申请人：[en]SUZHOU ZELGEN BIOPHARMACEUTICALS CO., LTD.;[zh]苏州泽璟生物制药股份有限公司

  公开号：WO2022188819A1

  公开（公告）日：2022-09-15

  本发明涉及SOS1蛋白水解调节剂及其制备方法和应用。具体地，本发明化合物具有式(I)所示结构，本发明还公开了所述化合物的制备方法及其作为SOS1蛋白水解调节剂的用途，本发明化合物对SOS1水解具有很好的选择性调节作用。
• OXAZOLIDONE COMPOUNDS, METHOD FOR PREPARING AND APPLICATION THEREOF
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP2947085B1

  公开（公告）日：2017-09-13
• THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN
  申请人：Kyle Donald J.

  公开号：US20100256111A1

  公开（公告）日：2010-10-07

  The invention provides a compound of formula (I): (where R 1 , Q, A and R 2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.
• US7767699B2
  申请人：——

  公开号：US7767699B2

  公开（公告）日：2010-08-03