2-(((2-aminoethyl)(3-(4-benzylpiperidin-1-yl)propyl)amino)methyl)phenol | 1258448-62-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-(((2-aminoethyl)(3-(4-benzylpiperidin-1-yl)propyl)amino)methyl)phenol
• 英文别名: 2-[[2-aminoethyl-[3-(4-benzylpiperidin-1-yl)propyl]amino]methyl]phenol
• CAS: 1258448-62-2
• 化学式: C₂₄H₃₅N₃O
• 分子量: 381.561
• InChiKey: VFRKHXYYTRGOGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  tert-butyl 2-((3-(4-benzylpiperidin-1-yl)propyl)(2-tert-butoxybenzyl)amino)ethylcarbamate 、 氨 以 甲醇 为溶剂， 以The product was isolated as pale yellow oil (60%)的产率得到2-(((2-aminoethyl)(3-(4-benzylpiperidin-1-yl)propyl)amino)methyl)phenol
  参考文献：
  名称：

  Compositions and methods for imaging tissues, organs and tumors

  摘要：

  本发明涉及化合物及其相关的铝靶和锇复合物，适用于组织、器官或肿瘤的成像或治疗。在另一实施例中，本发明涉及使用放射性标记的金属复合物成像组织、器官或肿瘤的方法，特别是对于表达某些受体的组织、器官或肿瘤，这些受体与本发明的化合物或复合物具有亲和性。本发明还涉及治疗癌症的方法，特别是那些表达某些受体的癌细胞系，这些受体与本发明的化合物或复合物具有亲和性。在另一实施例中，本发明提供了使用具有与要成像和/或抑制的受体或神经受体亲和性的本发明化合物或复合物成像和/或抑制受体或神经受体的方法。

  公开号：

  US08747810B2

文献信息

• COMPOSITIONS AND METHODS FOR IMAGING TISSUES, ORGANS AND TUMORS
  申请人：Mahmood Ashfaq

  公开号：US20120269724A1

  公开（公告）日：2012-10-25

  The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled metal complexes, particularly tissues, organs, or tumors which express certain receptors to which the compounds or complexes of the invention have an affinity. The present invention also relates to methods of treating cancer, particularly those cancer lines which express certain receptors to which the compounds or complexes of the invention have an affinity. In yet another embodiment, the present invention provides methods of imaging and/or inhibiting receptors or neuroreceptors using compounds or complexes of the invention which have an affinity for the receptor or neuroreceptor to be imaged and/or inhibited.

  本发明涉及化合物及其相关的锝和铼配合物，适用于组织、器官或肿瘤的成像或治疗。在另一实施例中，本发明涉及使用放射标记的金属配合物成像组织、器官或肿瘤的方法，特别是那些表达本发明化合物或配合物具有亲和力的特定受体的组织、器官或肿瘤。本发明还涉及治疗癌症的方法，特别是那些表达本发明化合物或配合物具有亲和力的特定受体的癌细胞系。在另一实施例中，本发明提供了使用具有与待成像和/或抑制的受体或神经受体具有亲和力的本发明化合物或配合物成像和/或抑制受体或神经受体的方法。
• US8747810B2
  申请人：——

  公开号：US8747810B2

  公开（公告）日：2014-06-10
• [EN] COMPOSITIONS AND METHODS FOR IMAGING TISSUES, ORGANS AND TUMORS<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'IMAGERIE DE TISSUS, ORGANES ET TUMEURS
  申请人：HARVARD COLLEGE

  公开号：WO2010144891A1

  公开（公告）日：2010-12-16

  The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled metal complexes, particularly tissues, organs, or tumors which express certain receptors to which the compounds or complexes of the invention have an affinity. The present invention also relates to methods of treating cancer, particularly those cancer lines which express certain receptors to which the compounds or complexes of the invention have an affinity. In yet another embodiment, the present invention provides methods of imaging and/or inhibiting receptors or neuroreceptors using compounds or complexes of the invention which have an affinity for the receptor or neuroreceptor to be imaged and/or inhibited.