2-(2-amino-4-pyrrolidin-1-yl-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridin-7-ol | 1189165-91-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-(2-amino-4-pyrrolidin-1-yl-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridin-7-ol
• 英文别名: 2-(2-Amino-4-pyrrolidin-1-ylphenyl)-4,5,6,7-tetrahydro-[1,3]thiazolo[4,5-c]pyridin-7-ol
• CAS: 1189165-91-0
• 化学式: C₁₆H₂₀N₄OS
• 分子量: 316.427
• InChiKey: FNSBUPSAUWIRFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE)
  申请人：——

  公开号：US20030130273A1

  公开（公告）日：2003-07-10

  The present application describes novel hydantoin derivatives of formula (I): 1 or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 11 , and n are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF-&agr; converting enzyme (TACE), aggrecanase, or a combination thereof.

  本申请描述了具有以下式(I)的新型咪唑啉衍生物：1或其药用可接受的盐或前药形式，其中A、B、R1、R2、R3、R4、R5、R6、R7、R11和n在本说明书中有定义，这些衍生物可用作基质金属蛋白酶（MMP）、TNF-α转化酶（TACE）、聚集素酶的抑制剂，或其组合。
• [EN] 2-ARYL- AND 2-HETEROARYLTHIAZOLYL COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF<br/>[FR] COMPOSÉS DE 2-ARYL- ET 2-HÉTÉROARYLTHIAZOLYLE, ET PROCÉDÉS CORRESPONDANTS D'ÉLABORATION ET D'UTILISATION
  申请人：WYETH CORP

  公开号：WO2009120849A1

  公开（公告）日：2009-10-01

  The present invention discloses fused heterobicyclic 2-aryl- and 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumor growth in particular and to treat diseases or disorders associated with securin (Formula I) and pharmaceutically acceptable salts thereof, wherein A is H, C1-C3 alkyi, or acetyl; Z is NR3 or O; Q is -NR1R2, - NR3N(R3)2. - NR3OR3, or -OH.

  本发明公开了融合的杂双环2-芳基和2-杂芳基噻唑基化合物及其药用可接受的盐和酯，用于抑制癌细胞的生长，特别是抑制人类乳腺癌肿瘤的生长，并用于治疗与蛋白质分离素（化学式I）和其药用可接受的盐相关的疾病或紊乱，其中A为H，C1-C3烷基，或乙酰基；Z为NR3或O；Q为-NR1R2，- NR3N(R3)2，- NR3OR3，或-OH。
• 2-Aryl-and 2-Heteroarylthiazolyl Compounds, Methods for Their Preparation and Use Thereof
  申请人：Zhang Nan

  公开号：US20090270447A1

  公开（公告）日：2009-10-29

  The present invention discloses fused heterobicyclic 2-aryl- and 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumor growth in particular and to treat diseases or disorders associated with securin.

  本发明揭示了熔合的异杂双环2-芳基-和2-杂芳基噻唑基化合物及其药学上可接受的盐和酯，对于抑制癌细胞生长，特别是抑制人乳腺癌肿瘤生长以及治疗与securin相关的疾病或紊乱有用。
• HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES
  申请人：Bristol-Myers Squibb Company

  公开号：EP1397137B1

  公开（公告）日：2009-10-14
• US6890915B2
  申请人：——

  公开号：US6890915B2

  公开（公告）日：2005-05-10