Bis-(2-chloro-phenyl)-phenyl-methanol | 61593-03-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Bis-(2-chloro-phenyl)-phenyl-methanol
• 英文别名: Bis(2-chlorophenyl)-phenylmethanol
• CAS: 61593-03-1
• 化学式: C₁₉H₁₄Cl₂O
• 分子量: 329.226
• InChiKey: WHKWRNPCZOEOEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Bis-(2-chloro-phenyl)-phenyl-methanol 在 氯化亚砜 、 三乙胺 作用下， 以 乙腈 为溶剂， 生成 1-(2,2'-dichloro-trityl)-1H-imidazole
  参考文献：
  名称：

  Bartroli; Alguero; Boncompte, Arzneimittel-Forschung/Drug Research, 1992, vol. 42, # 6, p. 832 - 835

  摘要：

  DOI：

文献信息

• Dosing form for a polymer support, use of said dosing form in organic chemical synthesis and method for production of said dosing form
  申请人：H. Lundbeck A/S

  公开号：US20030138847A1

  公开（公告）日：2003-07-24

  A dosing form for a polymer support for organic chemical synthesis in a solvent medium comprising a fixed weight amount of beads of a polymer containing functional groups, which polymer is insoluble in the solvent for the intended synthesis, is provided as compressed tablets of essentially equal weight and composition wherein the polymer beads are essentially intact and are released as such when the tablets are disintegrated in said solvent. Use of the dosing form is made in conventional synthesis, in parallel synthesis, in split and mix synthesis and/or combinatorial chemistry. In a method for producing the dosing form, beads of a polymer having functional gropusgroups is compressed into tablets after pre-treatment with an aprotic organic solvent groups are compressed into tablets after pre-treatment with an aprotic organic solvent.

  一种在溶剂介质中用于有机化学合成的聚合物支撑剂的给药形式，由固定重量的含有官能团的聚合物珠子组成，该聚合物不溶于预定合成的溶剂中，其形式为重量和成分基本相同的压缩片剂，其中聚合物珠子基本完好无损，当片剂在所述溶剂中崩解时就会释放出来。 在传统合成、并行合成、分拆混合合成和/或组合化学中均可使用这种配料形式。 在生产定量给药形式的方法中，具有官能团的聚合物珠子在用壬烷有机溶剂预处理后被压缩成片剂。
• VERFAHREN ZUR HERSTELLUNG VON INDOLDERIVATEN AN FESTER PHASE
  申请人：MERCK PATENT GmbH

  公开号：EP1222167A2

  公开（公告）日：2002-07-17
• DOSING FORM FOR A POLYMER SUPPORT, USE OF SAID DOSING FORM IN ORGANIC CHEMICAL SYNTHESIS AND METHOD FOR PRODUCTION OF SAID DOSING FORM
  申请人：H. Lundbeck A/S

  公开号：EP1268050A2

  公开（公告）日：2003-01-02
• [DE] VERFAHREN ZUR HERSTELLUNG VON INDOLDERIVATEN AN FESTER PHASE<br/>[EN] METHOD FOR PRODUCING INDOLE DERIVATIVES ON A SOLID PHASE<br/>[FR] PROCEDE DE PREPARATION DE DERIVES D'INDOL SUR UNE PHASE SOLIDE
  申请人：MERCK PATENT GMBH

  公开号：WO2001023353A2

  公开（公告）日：2001-04-05

  Die Erfindung betrifft ein Verfahren zur Herstellung von Indol-Derivaten an fester Phase, wobei die Anbindung an die feste Phase am Indol-Stickstoff durch Transacetalisierung von dialkoxymethylgeschützten Indolen mit einer festen Phase erfolgt, die vicinale Diolgruppen trägt und nach Synthesechemie an der festen Phase, das funktionalisierte Indol-Derivat 'spurlos' von der festen Phase gespalten wird.
• [EN] DOSING FORM FOR A POLYMER SUPPORT, USE OF SAID DOSING FORM IN ORGANIC CHEMICAL SYNTHESIS AND METHOD FOR PRODUCTION OF SAID DOSING FORM<br/>[FR] FORME DE DOSAGE POUR SUPPORT POLYMERE, UTILISATION DE LADITE FORME DANS LA SYNTHESE CHIMIQUE ORGANIQUE ET PROCEDE DE FABRICATION DE LADITE FORME DE DOSAGE
  申请人：LUNDBECK & CO AS H

  公开号：WO2001068598A2

  公开（公告）日：2001-09-20

  A dosing form for a polymer support for organic chemical synthesis in a solvent medium comprising a fixed weight amount of beads of a polymer containing functional groups, which polymer is insoluble in the solvent for the intended synthesis, is provided as compressed tablets of essentially equal weight and composition wherein the polymer beads are essentially intact and are released as such when the tablets are disintegrated in said solvent. Use of the dosing form is made in conventional synthesis, in parallel synthesis, in split and mix synthesis and/or combinatorial chemistry. In a method for producing the dosing form, beads of a polymer having functional groups are compressed into tablets after pre-treatment with an aprotic organic solvent.