1-piperidino-3-methylbut-3-ene | 36794-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-piperidino-3-methylbut-3-ene
• 英文别名: 1-(3-Methylbut-3-enyl)piperidine
• CAS: 36794-57-7
• 化学式: C₁₀H₁₉N
• 分子量: 153.268
• InChiKey: VIWHNYOMFFYNKA-UHFFFAOYSA-N

物化性质

• 沸点：
  204.7±19.0 °C(Predicted)
• 密度：
  0.853±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (Z)-2-methyl-4-piperidin-1-ylbut-2-ene-1-sulfonic acid 生成 1-piperidino-3-methylbut-3-ene
  参考文献：
  名称：

  Reductive transformation of isoprenoid cyclosulfonates into linear homoallylic alcohols and amines

  摘要：

  DOI：

  10.1007/bf00948515

文献信息

• Heavier Alkaline Earth Catalysts for the Intermolecular Hydroamination of Vinylarenes, Dienes, and Alkynes
  作者：Christine Brinkmann、Anthony G. M. Barrett、Michael S. Hill、Panayiotis A. Procopiou

  DOI：10.1021/ja209135t

  日期：2012.2.1

  nucleophilicity. Hydroamination of conjugated dienes yielded isomeric products via η(3)-allyl intermediates and their relative distributions were explained through stereoelectronic considerations. The ability to carry out the hydroamination of internal alkynes was found to be dramatically dependent upon the identity of the alkyne substituents while reactions employing terminal alkynes resulted in the

  较重的第 2 族络合物 [MN(SiMe(3))(2)}(2)](2)(1, M = Ca; 2, M = Sr) 和 [MCH(SiMe(3)) (2)}(2)(THF)(2)] (3, M = Ca; 4, M = Sr) 被证明是温和条件下乙烯基芳烃和二烯分子间加氢胺化的有效预催化剂。初步研究表明，酰胺预催化剂 1 和 2 虽然在绝对活性方面受到氨基转移行为的影响，但对聚合/低聚副反应具有更高的稳定性。在每种情况下，锶物质 2 和 4 都被发现优于它们的钙同类物。哌啶与对位取代苯乙烯的反应表明催化循环中烯烃插入的速率决定性，而环仲胺的添加容易程度被发现取决于环的大小，并被认为是不同胺亲核性的结果。共轭二烯的加氢胺化通过 η(3)-烯丙基中间体产生异构产物，并通过立体电子考虑解释了它们的相对分布。发现进行内部炔烃的加氢胺化的能力极大地取决于炔烃取代基的身份，而使用末端炔烃的反应导致不溶性和非反应性第
• POLARIZATION SOURCE FOR DYNAMIC NUCLEAR POLARIZATION, COMPOSITION, COMPOSITION FOR DYNAMIC NUCLEAR POLARIZATION, METHOD FOR HYPERPOLARIZATION, HYPERPOLARIZED SUBSTANCE AND NMR MEASUREMENT METHOD
  申请人：Kyushu University, National University Corporation

  公开号：EP3932911A1

  公开（公告）日：2022-01-05

  Provided is a polarization source having high oxygen resistance and capable of stably transitioning the spin polarization of electron to nucleus even in an environment where oxygen exists. A polarization source for dynamic nuclear polarization containing a molecule represented by the following general formula. One to six of Z1 to Z10 each represent N, and the others each independently represent C-R. R represents a hydrogen atom or a substituent. n represents an integer of 1 to 4.

  本发明提供了一种极化源，该极化源具有较高的抗氧性，即使在存在氧气的环境中也能稳定地将电子的自旋极化转变为原子核的自旋极化。一种用于动态核极化的极化源，含有由以下通式表示的分子。Z1至Z10中的1至6个各自代表N，其他各自独立地代表C-R。R 代表氢原子或取代基。n 代表 1 至 4 的整数。
• A PERSONAL CARE COMPOSITION
  申请人：Unilever N.V.

  公开号：EP3664775B1

  公开（公告）日：2021-03-17
• [EN] NEPRILYSIN INHIBITORS<br/>[FR] INHIBITEURS DE NÉPRILYSINE
  申请人：THERAVANCE INC

  公开号：WO2012166387A1

  公开（公告）日：2012-12-06

  In one aspect, the invention relates to compounds having the formula: (I) where R1, R2, R3, R4, and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.