{4-[1-(3,4-dimethoxybenzyl)piperidin-4-yl]benzyl}amine | 783348-22-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: {4-[1-(3,4-dimethoxybenzyl)piperidin-4-yl]benzyl}amine
• 英文别名: [4-[1-[(3,4-Dimethoxyphenyl)methyl]piperidin-4-yl]phenyl]methanamine
• CAS: 783348-22-1
• 化学式: C₂₁H₂₈N₂O₂
• 分子量: 340.466
• InChiKey: DFXPUVJYXUAAIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  47.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Heterocyclic compound containing nitrogen atom and use thereof
  申请人：Habashita Hiromu

  公开号：US20070043079A1

  公开（公告）日：2007-02-22

  The present invention relates to a medicament comprising the compound of formula (I) wherein all symbols have the same meanings as defined in the specification, a salt thereof or a prodrug thereof. The compound of the present invention is useful for the prevention and/or treatment of immune diseases such as various types of inflammation, autoimmune disease, allergic diseases, etc.; infection concerning inflammation or HIV infections (e.g. asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis, etc.), organ transplantation rejection, immunosuppression, psoriasis, multiple sclerosis, optic neuritis, polymyalgia rheumatica syndrome, uveitis, vasculitis, human immunodeficiency virus infection (acquired immunodeficiency syndrome etc.), atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, osteoarthritis, ischemic reperfusion injury, acute respiratory distress syndrome, shock accompanying bacteria infection, diabetes, cancer metastasis, atherosclerosis, etc.).

  本发明涉及一种药物，包括式（I）的化合物，其中所有符号的含义如规范中所定义，其盐或前药。本发明的化合物对于预防和/或治疗免疫性疾病，如各种类型的炎症，自身免疫性疾病，过敏性疾病等；感染有关炎症或HIV感染（例如哮喘，肾炎，肾病，肝炎，关节炎，类风湿性关节炎，鼻炎，结膜炎，溃疡性结肠炎等），器官移植排异反应，免疫抑制，牛皮癣，多发性硬化症，视神经炎，多肌痛风综合症，葡萄膜炎，血管炎，人类免疫缺陷病毒感染（获得性免疫缺陷综合症等），特应性皮炎，荨麻疹，过敏性支气管肺曲霉病，过敏性嗜酸性胃肠炎，骨关节炎，缺血再灌注损伤，急性呼吸窘迫综合症，伴随细菌感染的休克，糖尿病，癌转移，动脉粥样硬化等具有益处。
• NITROGENOUS HETEROCYCLIC COMPOUND AND USE THEREOF
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1616862A1

  公开（公告）日：2006-01-18

  The present invention relates to a medicament comprising the compound of formula (I) wherein all symbols have the same meanings as defined in the specification, a salt thereof or a prodrug thereof The compound of the present invention is useful for the prevention and/or treatment of immune diseases such as various types of inflammation, autoimmune disease, allergic diseases, etc.; infection concerning inflammation or HIV infections (e.g. asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis, etc.), organ transplantation rejection, immunosuppression, psoriasis, multiple sclerosis, optic neuritis, polymyalgia rheumatica syndrome, uveitis, vasculitis, human immunodeficiency virus infection (acquired immunodeficiency syndrome etc.), atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, osteoarthritis, ischemic reperfusion injury, acute respiratory distress syndrome, shock accompanying bacteria infection, diabetes, cancer metastasis, atherosclerosis, etc.).

  本发明涉及一种包含式 (I) 化合物的药物 本发明的化合物可用于预防和/或治疗免疫性疾病，如各种类型的炎症、自身免疫性疾病、过敏性疾病等；有关炎症或 HIV 感染的感染（如哮喘、肾炎、肾病、肝炎、关节炎、类风湿性关节炎、鼻炎、结膜炎、溃疡性结肠炎等。免疫抑制、牛皮癣、多发性硬化症、视神经炎、多发性风湿性关节炎综合征、葡萄膜炎、血管炎、人体免疫缺陷病毒感染（获得性免疫缺陷综合征等）、特应性皮炎、结膜炎、溃疡性结肠炎等。过敏性支气管肺曲霉病、过敏性嗜酸性粒细胞性胃肠炎、骨关节炎、缺血再灌注损伤、急性呼吸窘迫综合征、细菌感染引起的休克、糖尿病、癌症转移、动脉粥样硬化等）。