4-{3-[2-(5-Cyclopropylcarbamoyl-2-methyl-phenylamino)-5-(cyclopropylmethylcarbamoyl)-thiazol-4-yl]-phenyl}-piperidine-1-carboxylic acid methyl ester | 808738-14-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-{3-[2-(5-Cyclopropylcarbamoyl-2-methyl-phenylamino)-5-(cyclopropylmethylcarbamoyl)-thiazol-4-yl]-phenyl}-piperidine-1-carboxylic acid methyl ester
• 英文别名: Methyl 4-[3-[2-[5-(cyclopropylcarbamoyl)-2-methylanilino]-5-(cyclopropylmethylcarbamoyl)-1,3-thiazol-4-yl]phenyl]piperidine-1-carboxylate
• CAS: 808738-14-9
• 化学式: C₃₂H₃₇N₅O₄S
• 分子量: 587.743
• InChiKey: WOHLTZKNMPFWJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  42
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  141
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• P-38 inhibitors
  申请人：——

  公开号：US20040254236A1

  公开（公告）日：2004-12-16

  Provided are 5-membered heterocycle-based p38 kinase, including p38&agr; and p38&bgr; kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.

  提供了基于5-成员杂环的p38激酶抑制剂，包括p38&agr;和p38&bgr;激酶。还提供了含有这些化合物的药物组合物。还提供了这些化合物和组合物的使用方法，包括治疗、预防或改善p38激酶介导的疾病和障碍的一个或多个症状的方法，包括但不限于炎症性疾病和障碍。
• P-38 INHIBITORS
  申请人：Dong Qing

  公开号：US20100004298A1

  公开（公告）日：2010-01-07

  Provided are 5-membered heterocycle-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.

  提供了基于5-成员杂环的p38激酶（包括p38α和p38β激酶）抑制剂。还提供了含有这些化合物的药物组合物。还提供了这些化合物和组合物的使用方法，包括治疗、预防或缓解p38激酶介导的疾病和疾病的一个或多个症状的方法，包括但不限于炎症性疾病和疾病。
• 5-MEMBERED HETEROCYCLE-BASED P-38 INHIBITORS
  申请人：Novartis AG

  公开号：EP1635824A2

  公开（公告）日：2006-03-22
• US7652044B2
  申请人：——

  公开号：US7652044B2

  公开（公告）日：2010-01-26
• [EN] 5-MEMBERED HETEROCYCLE-BASED P-38 INHIBITORS<br/>[FR] INHIBITEURS DE P-38
  申请人：TRIAD THERAPEUTICS INC

  公开号：WO2005000298A2

  公开（公告）日：2005-01-06

  Provided are aminoaryl substituted 5-membered heterocycle-based p38 kinase, including p38alfa and p38beta. Pharmaceutical compositions containing the compounds are also provided. Method of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.