| 1070766-34-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 1070766-34-5
• 化学式: C₃₄H₃₅N₃O₇
• 分子量: 597.668
• InChiKey: JUDCPEPBOWRRER-OJDZSJEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.55
• 重原子数：
  44.0
• 可旋转键数：
  11.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  117.06
• 氢给体数：
  2.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  3-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-6-(methoxymethyl)furo[2,3-d]pyrimidin-2(3H)-one 在 ammonium hydroxide 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以85%的产率得到
  参考文献：
  名称：

  The 6-Methoxymethyl Derivative Of Pyrrolo-Dc For Selective Fluorometric Detection Of Guanosine-Containing Sequences

  摘要：

  The beta-cyanoethyl phosphosphoramidite derivatives of 6-methyl- and 6-methoxymethyl-3-(2-deoxy-beta-D-ribofuranosyl)-3H-pyrrolo[2,3-d]pyrimidin-2-one have been synthesized. These monomers have been employed for oligodeoxynucleolide synthesis to evaluate their effect on duplex stability and ability to fluorometrically report on hybridization. The structurally conservative 6-methroxymethyl-substitution results in a pyrrolocylidine that is stabilizing toward hybrid formation (Delta Tm = +1.3 degrees C) whereas the known 6-methylpyrrolocytidine is destabilizing (Delta Tm = -4.7 degrees C), in the sequence examined. The 6-methoxymethylpyrrolocytidine retains excellent mismatch discrimination and its fluorescence is selectively quenched when hybridized to a match oligodeoxynucleotide sequence. The quenching of fluorescence for an internal position is approximately three-fold, whereas a terminal position (5'-end or 3'-end) experienced approximately two-fold decrease in the fluorescence intensity.

  DOI：

  10.1080/15257770701489839