4-Oxopiperidine-3,5-dicarboxylic acid | 137506-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-Oxopiperidine-3,5-dicarboxylic acid
• CAS: 137506-75-3
• 化学式: C₇H₉NO₅
• 分子量: 187.15
• InChiKey: HRVGVJXJUIVOPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Piperidone derivatives and medical uses thereof
  申请人：Heinrich-Pette-Institut

  公开号：EP2036556A1

  公开（公告）日：2009-03-18

  The present invention relates to compositions comprising 4-Oxo-piperidine-carboxylates and derivatives thereof, for example derivatives substituted with phenyl, nitrophenyl or benzyl groups. It also teaches the medical use of these and related compounds for treatment of retroviral diseases, in particular, HIV and HTLV, proliferative diseases, in particular CML and Trypanosomiasis.

  本发明涉及包含4-氧代哌啶羧酸酯及其衍生物的组合物，例如用苯基、硝基苯基或苄基取代的衍生物。它还教导了这些相关化合物的医药用途，用于治疗逆转录病毒性疾病，特别是HIV和HTLV，增殖性疾病，特别是慢性髓细胞白血病和锥虫病。
• Chemokine combinations to mobilize progenitor/stem cells
  申请人：Bridger J. Gary

  公开号：US20060035829A1

  公开（公告）日：2006-02-16

  Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 in combination with the CXCR2 chemokine GROβ, including its modified forms, are disclosed.

  使用与趋化因子受体CXCR4结合的化合物与CXCR2趋化因子GROβ及其改良形式结合，揭示了提高动物主体中祖细胞和干细胞数量的方法。
• Chemokine receptor binding heterocyclic compounds with enhanced efficacy
  申请人：Bridger J. Gary

  公开号：US20050059702A1

  公开（公告）日：2005-03-17

  Compounds that interact with the CXCR4 receptor are described. These compounds are useful in treating, for Example, HIV infection and inflammatory conditions such as rheumatoid arthritis, as well as asthma or cancer, and are useful in methods to elevate progenitor and stem cell counts as well as methods to elevate white blood cell counts.

  描述了与CXCR4受体相互作用的化合物。这些化合物在治疗HIV感染和炎症性疾病（如类风湿性关节炎）、哮喘或癌症方面非常有用，并且在提高祖细胞和干细胞计数以及提高白细胞计数的方法中也非常有用。
• CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY
  申请人：BRIDGER Gary J.

  公开号：US20090281308A1

  公开（公告）日：2009-11-12

  Compounds that interact with the CXCR4 receptor are described. These compounds are useful in treating, for Example, HIV infection and inflammatory conditions such as rheumatoid arthritis, as well as asthma or cancer, and are useful in methods to elevate progenitor and stem cell counts as well as methods to elevate white blood cell counts.

  描述了与CXCR4受体相互作用的化合物。这些化合物在治疗HIV感染和炎症疾病，如类风湿性关节炎、哮喘或癌症方面非常有用，并且在提高祖细胞和干细胞计数以及提高白细胞计数的方法中也非常有用。
• EP1615633A2
  申请人：——

  公开号：EP1615633A2

  公开（公告）日：2006-01-18