4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]piperidine | 1235382-80-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]piperidine
• 英文别名: 4-[2-(oxan-2-yloxy)ethoxy]piperidine
• CAS: 1235382-80-5
• 化学式: C₁₂H₂₃NO₃
• 分子量: 229.32
• InChiKey: ONIIQIGAHXZGEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  39.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]piperidine 、 甲基磺酰氯 生成 1-(methylsulfonyl)-4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]piperidine
  参考文献：
  名称：

  Cyclic compound having substituted phenyl group

  摘要：

  具有促进骨形成作用的低分子量化合物，其具有一般式（I）或其药理学上可接受的盐：

  公开号：

  US08410273B2

文献信息

• [5,6]HETEROCYCLIC COMPOUND
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2565185A1

  公开（公告）日：2013-03-06

  Abstract: An object of the present invention is to provide a novel low molecular weight compound exhibiting an osteogenesis-promoting action. This object is achieved by a compound having the general formula (I) or a pharmacologically acceptable salt thereof. In the general formula (I), R1 and R2 represent hydrogen atoms, and the like; R3 represents a hydrogen atom, and the like; X, Y, and Z represent nitrogen atoms, and the like; A represents a phenylene group, and the like; n represents 1 or 2, and the like; and V and W represent oxygen atoms, and the like.

  摘要：本发明的目的是提供一种表现出促进骨生成作用的新型低分子量化合物。该目的通过具有通式（I）或其药理学可接受的盐的化合物实现。在通式（I）中，R1和R2代表氢原子等；R3代表氢原子等；X、Y和Z代表氮原子等；A代表苯基等；n代表1或2等；V和W代表氧原子等。
• [EN] COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY<br/>[FR] COMPOSÉS ET COMPOSITIONS COMME MODULATEURS D'ACTIVITÉ DE GPR119
  申请人：IRM LLC

  公开号：WO2009105717A1

  公开（公告）日：2009-08-27

  The invention provides compounds of Formula (I): pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.

  该发明提供了Formula (I)的化合物：包括这些化合物的药物组合物以及使用这些化合物治疗或预防与GPR119活性相关的疾病或疾病的方法。
• [5, 6] HETEROCYCLIC COMPOUND
  申请人：Aoki Kazumasa

  公开号：US20130029964A1

  公开（公告）日：2013-01-31

  An object of the present invention is to provide a novel low molecular weight compound exhibiting an osteogenesis-promoting action. This object is achieved by a compound having the general formula (I) or a pharmacologically acceptable salt thereof. In the general formula (I), R 1 and R 2 represent hydrogen atoms, and the like; R 3 represents a hydrogen atom, and the like; X, Y, and Z represent nitrogen atoms, and the like; A represents a phenylene group, and the like; n represents 1 or 2, and the like; and V and W represent oxygen atoms, and the like.

  本发明的目的是提供一种新型低分子量化合物，具有促进骨生成作用。通过具有通式（I）或其药理学上可接受的盐来实现该目的。在通式（I）中，R1和R2代表氢原子等；R3代表氢原子等；X、Y和Z代表氮原子等；A代表苯基等；n代表1或2等；V和W代表氧原子等。
• CYCLIC COMPOUND HAVING SUBSTITUTED PHENYL GROUP
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2418203B1

  公开（公告）日：2013-12-11
• CYCLIC COMPOUND HAVING HETERO ATOM
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2380878B1

  公开（公告）日：2013-08-14