5'-Deoxy-5'-{[3-(methylsulfanyl)propyl]amino}adenosine | 67675-28-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: 5'-Deoxy-5'-{[3-(methylsulfanyl)propyl]amino}adenosine
• 英文别名: (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[(3-methylsulfanylpropylamino)methyl]oxolane-3,4-diol
• CAS: 67675-28-9
• 化学式: C₁₄H₂₂N₆O₃S
• 分子量: 354.43
• InChiKey: OKJWQLKYIDQHLH-IDTAVKCVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  157
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• [EN] AMINO ACID DEPLETION AGENTS AS ANTIPROLIFERATIVE AGENTS<br/>[FR] AGENTS D'APPAUVRISSEMENT EN ACIDES AMINÉS EN GUISE D'AGENTS ANTIPROLIFÉRATIFS
  申请人：UNIV CENTRAL FLORIDA RES FOUND INC

  公开号：WO2020047361A1

  公开（公告）日：2020-03-05

  Novel compounds are described which decrease the intracellular levels of leucine and methionine. Treatment with these amino acid depletion agents affects many metabolic and life processes which rely upon methionine, leucine and their derivatives. Methionine depletion not only inhibits protein synthesis, but also polyamine biosynthesis and significantly reduces intracellular pools of the native polyamines, spermidine and spermine. Since methionine restriction has been shown to mimic caloric restriction in life extension studies across multiple species, these compounds are also expected to extend lifespan by limiting methionine supply.

  描述了几种新的化合物，这些化合物能够降低细胞内亮氨酸和蛋氨酸的水平。使用这些氨基酸剥夺剂影响许多依赖蛋氨酸、亮氨酸及其衍生物的代谢和生命过程。蛋氨酸剥夺不仅抑制蛋白质合成，还抑制聚胺生物合成，并显著减少细胞内天然聚胺，即亚精胺和精胺的池。由于蛋氨酸限制在多个物种的生命延长研究中已被证明可以模仿卡路里限制，因此预计这些化合物通过限制蛋氨酸供应也能延长寿命。
• PLANT HAVING IMPROVED TOLERANCE TO VARIOUS ENVIRONMENTAL STRESSES, METHOD OF CONSTRUCTING THE SAME AND POLYAMINE METABOLISM-RELATING ENZYME GENE
  申请人：Toyobo Research Center Co., LTD.

  公开号：EP1329153A1

  公开（公告）日：2003-07-23

  The present invention relates to isolated plant-derived polyamine metabolism-related enzyme genes characterized in that their level of expression changes when exposed to environmental stress; antisense DNA or antisense RNA to such genes; plants and their progeny having improved environmental stress tolerance, in which such genes are retained in a stable manner; methods for producing such plants, and methods for producing calli of such plants; method for selecting transformed plants which grow improved more than plants lacking an exogenous polyamine metabolism-related enzyme gene; and microorganims and plants which are transformed by such genes

  本发明涉及分离的植物源多胺代谢相关酶基因，其特征在于当暴露于环境胁迫时它们的表达水平会发生变化；这些基因的反义DNA或反义RNA；具有改善的环境胁迫耐受性的植物及其后代，其中这些基因以稳定的方式保留；生产这种植物的方法和生产这种植物的胼胝体的方法；选择转化植物的方法，这种植物比缺乏外源多胺代谢相关酶基因的植物生长得更好；以及由这种基因转化的微生物和植物
• PLANT WITH IMPROVED ORGANOGENESIS AND METHOD OF CONSTRUCTING THE SAME
  申请人：Toyobo Research Center Co., LTD.

  公开号：EP1498027A1

  公开（公告）日：2005-01-19

  The invention relates to plants and their progeny with improved morphogenesis in a variety of organs; to a method for producing the plants; and to a method for producing calli.

  本发明涉及各种器官形态发生得到改善的植物及其后代；涉及生产这些植物的方法；还涉及生产胼胝体的方法。
• Plants with improved morphogenesis and method of constructing the same
  申请人：Toyo Boseki Kabushiki Kaisha

  公开号：EP2064943A2

  公开（公告）日：2009-06-03

  The invention relates to plants and their progeny with improved morphogenesis in a variety of organs; to a method for producing the plants; and to a method for producing calli.

  本发明涉及各种器官形态发生得到改善的植物及其后代；涉及生产这些植物的方法；还涉及生产胼胝体的方法。
• Method and compositions to promote plant growth in metal contaminated environments
  申请人：Larsen Paul Brian

  公开号：US10184129B2

  公开（公告）日：2019-01-22

  The disclosure provides polynucleotides, polypeptides, transgenic plants, cells and vectors useful for crop plants to augment the basal level of aluminum and heavy metal tolerance.

  本公开提供了对作物植物有用的多核苷酸、多肽、转基因植物、细胞和载体，以提高铝和重金属耐受性的基础水平。