4-(2-fluorobenzyl)-4-methoxypiperidine | 191327-98-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(2-fluorobenzyl)-4-methoxypiperidine
• 英文别名: 4-[(2-Fluorophenyl)methyl]-4-methoxypiperidine
• CAS: 191327-98-7
• 化学式: C₁₃H₁₈FNO
• 分子量: 223.29
• InChiKey: IPFVIPYBXCCGER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Dopamine D2 receptor ligands
  申请人：The Broad Institute, Inc.

  公开号：US10633336B2

  公开（公告）日：2020-04-28

  The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity. The present invention relates to novel compounds that modulate dopamine D2 receptors. In particular, compounds of the present invention show functional selectivity at the dopamine D2 receptors and exhibit selectivity downstream of the D2 receptors, on the 0-arrestin pathway and/or on the cAMP pathway.

  本发明涉及新型多巴胺D2受体配体。本发明进一步涉及具有功能偏倚的多巴胺 D2 受体配体，以及使用这些化合物治疗或预防与多巴胺能活性失调相关的中枢神经系统和全身性疾病。本发明涉及调节多巴胺 D2 受体的新型化合物。特别是，本发明的化合物在多巴胺 D2 受体上表现出功能选择性，并在 D2 受体下游、0-arrestin 通路和/或 cAMP 通路上表现出选择性。
• SUBSTITUTED PIPERIDINE DERIVATIVES AS SELECTIVE AGONISTS OF 5-HT RECEPTORS
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP0862568A1

  公开（公告）日：1998-09-09
• DOPAMINE D2 RECEPTOR LIGANDS
  申请人：The Broad Institute, Inc.

  公开号：US20180155283A1

  公开（公告）日：2018-06-07

  The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopammode inergic activity. The present invention relates to novel compounds that modulate dopamine D2 receptors. In particular, compounds of the present invention show functional selectivity at the dopamine D2 receptors and exhibit selectivity downstream of the D2 receptors, on the 0-arrestin pathway and/or on the cAMP pathway.
• US6048878A
  申请人：——

  公开号：US6048878A

  公开（公告）日：2000-04-11
• [EN] SUBSTITUTED PIPERIDINE DERIVATIVES AS SELECTIVE AGONISTS OF 5-HT RECEPTORS<br/>[FR] DERIVES SUBSTITUES DE LA PIPERIDINE COMME AGONISTES SELECTIFS POUR LES RECEPTEURS 5-HT
  申请人：MERCK SHARP & DOHME LIMITED

  公开号：WO1997018202A1

  公开（公告）日：1997-05-22

  (EN) A compound of formula (I), or a salt or prodrug thereof, wherein G is attached at position 3 or 4 of the piperidine ring and represents halogen or C1-6 alkoxy; R1 represents C3-6 alkenyl, C3-6 alkynyl, aryl(C1-6)alkyl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted; processes for its preparation and its use in therapy, particularly in the treatment of migraine.(FR) Composé de la formule (I), sel ou précurseur de ce composé. Dans cette formule, G est rattaché en position 3 ou 4 au noyau pipéridine, et représente halogène ou alcoxy C1-6; R1 représente alcényle C3-6, alcynyle C3-6, arylalkyle C1-6 ou hétéroarylalkyle C1-6, tous ces groupes pouvant éventuellement être substitués. L'invention concerne également des procédés pour préparer ce composé et son utilisation thérapeutique, en particulier pour le traitement de migraines.