4-{3,5-difluoro-4-[(1-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]methyl}hexahydropyridin-4-yl)oxy]phenyl}-1-methanesulfonylhexahydropyridine | 1287685-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-{3,5-difluoro-4-[(1-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]methyl}hexahydropyridin-4-yl)oxy]phenyl}-1-methanesulfonylhexahydropyridine
• 英文别名: 4-(3,5-difluoro-4-(1-((1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)hexahydropyridin-4-yloxy)phenyl)-1-(methylsulfonyl)hexahydropyridine；4-(3,5-difluoro-4-(1-((1-methyl-3-(trifluoromethaneyl)-1H-pyrazol-5-yl)methyl)piperidin-4-yloxy)phenyl)-1-(methylsulfonyl)piperidine；4-{3,5-difluoro-4-[(1-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]methyl}piperidin-4-yl)oxy]phenyl}-1-methanesulfonylpiperidine；4-(3,5-difluoro-4-(1-((1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)piperidin-4-yloxy)phenyl)-1-(methylsulfonyl)piperidine；4-[3,5-Difluoro-4-[1-[[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]piperidin-4-yl]oxyphenyl]-1-methylsulfonylpiperidine
• CAS: 1287685-57-7
• 化学式: C₂₃H₂₉F₅N₄O₃S
• 分子量: 536.566
• InChiKey: ZVDDYYQIYSBLBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  76
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY<br/>[FR] COMPOSES ET COMPOSITIONS COMME MODULATEURS DE L'ACTIVITE DE GPR119
  申请人：IRM LLC

  公开号：WO2011044001A1

  公开（公告）日：2011-04-14

  The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.

  这项发明提供了化合物，包括这些化合物的药物组合物，以及使用这些化合物治疗或预防与GPR119活性相关的疾病或紊乱的方法。
• COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
  申请人：Azimioara Mihai

  公开号：US20110245220A1

  公开（公告）日：2011-10-06

  The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.

  该发明提供了化合物，包括这些化合物的制药组合物和使用这些化合物治疗或预防与GPR119活性相关的疾病或障碍的方法。
• US8575168B2
  申请人：——

  公开号：US8575168B2

  公开（公告）日：2013-11-05