1-(2-Fluoro-4-nitrophenyl)-3-methylpiperidin-4-one | 648920-90-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(2-Fluoro-4-nitrophenyl)-3-methylpiperidin-4-one
• CAS: 648920-90-5
• 化学式: C12H13FN2O3
• 分子量: 252.24
• InChiKey: MLQFSSFSGHFJOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  66.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoprotein sites
  申请人：WOCKHARDT LIMITED

  公开号：US20040063954A1

  公开（公告）日：2004-04-01

  The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel cyano-(substituted)-methylenepiperidinophenyl oxazolidinone derivatives, processes for making the compounds, as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.

  本发明提供了具有高抗微生物活性的代理，用于预防和治疗传染病。因此，本发明提供了新型的氰基-（取代）-亚甲基哌啶基苯氧唑烷衍生物、制备该化合物的方法，以及包含该衍生物作为活性成分的抗微生物组合物和使用该衍生物治疗细菌感染的方法。
• ANTIBACTERIAL SUBSTITUTED CYANOMETHYL(ENE)PIPERIDINOPHENYL OXAZOLIDINONES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Patel, Mahesh V.

  公开号：EP1565461A2

  公开（公告）日：2005-08-24
• US7405228B2
  申请人：——

  公开号：US7405228B2

  公开（公告）日：2008-07-29
• [EN] ANTIBACTERIAL CYANO-(SUBSTITUTED)-METHYLENEPIPERIDINOPHENYL OXAZOLIDINONES TARGETING MULTIPLE RIBONUCLEOPROTEIN SITES<br/>[FR] ANTIBACTERIENS A BASE DE METHYLENEPIPERIDINOPHENYL OXAZOLIDINONES A SUBSTITUTION CYANO CIBLANT DE MULTIPLES SITES DE RIBONUCLEOPROTEINES
  申请人：PATEL MAHESH V

  公开号：WO2004007489A2

  公开（公告）日：2004-01-22

  The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel cyano-(substituted)-methylenepiperidinophenyl oxazolidinone derivatives, processes for making the compounds, as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.