| 145744-01-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 145744-01-0
• 化学式: C₅₂H₆₅N₆O₈PSi
• 分子量: 961.183
• InChiKey: JWSGDKOCIDFSCC-LTMMGAFGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.61
• 重原子数：
  68.0
• 可旋转键数：
  17.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  151.76
• 氢给体数：
  1.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  2-氰乙基N,N-二异丙基氯亚磷酰胺 、 在 N,N-二异丙基乙胺 作用下， 反应 5.0h， 以83%的产率得到
  参考文献：
  名称：

  Tricyclic “oxadiazaphosphorine oxide” guanosines: A new strategy to the protection of guanine bases during RNA synthesis

  摘要：

  A novel strategy for simultaneously protecting the lactam and N2-amino functions of guanine nucleosides is reported. N2-benzoylated guanosines were readily converted into tricyclic "oxadiazaphosphorine oxide" guanosines upon reaction with N,N-diisopropylphosphoramidous dichloride followed by oxidation with t-butyl hydroperoxide. The tricyclic guanine derivative is reconverted readily to the natural guanine aglycone upon treatment with ethylenediamine/ethanol (1:4, 1 min, r.t.).

  DOI：

  10.1016/s0040-4039(00)61764-1
• 作为产物：
  描述：

  在 叔丁基过氧化氢 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以78%的产率得到
  参考文献：
  名称：

  Tricyclic “oxadiazaphosphorine oxide” guanosines: A new strategy to the protection of guanine bases during RNA synthesis

  摘要：

  A novel strategy for simultaneously protecting the lactam and N2-amino functions of guanine nucleosides is reported. N2-benzoylated guanosines were readily converted into tricyclic "oxadiazaphosphorine oxide" guanosines upon reaction with N,N-diisopropylphosphoramidous dichloride followed by oxidation with t-butyl hydroperoxide. The tricyclic guanine derivative is reconverted readily to the natural guanine aglycone upon treatment with ethylenediamine/ethanol (1:4, 1 min, r.t.).

  DOI：

  10.1016/s0040-4039(00)61764-1