2-methyl-2-(propane-2-sulfonyl)-propionic acid | 1017539-77-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 2-methyl-2-(propane-2-sulfonyl)-propionic acid
• 英文别名: 2-Methyl-2-[(1-methylethyl)sulfonyl]propanoic acid；2-methyl-2-propan-2-ylsulfonylpropanoic acid
• CAS: 1017539-77-3
• 化学式: C₇H₁₄O₄S
• 分子量: 194.252
• InChiKey: UWUIBWWZAKZXIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Compounds which Modulate the CB2 Receptor
  申请人：Berry Angela

  公开号：US20080081822A1

  公开（公告）日：2008-04-03

  Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

  公式（I）的化合物已被披露。根据本发明的化合物与CB2受体结合，并且是CB2受体的激动剂、拮抗剂或反向激动剂，可用于治疗炎症。那些是激动剂的化合物还可用于治疗疼痛。
• HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS
  申请人：Hadida-Ruah Sara Sabina

  公开号：US20110306607A1

  公开（公告）日：2011-12-15

  The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及杂环色烯-螺环哌啶酰胺类化合物，其可用作离子通道抑制剂。本发明还提供了包含本发明化合物的药学上可接受的组合物，并提供了使用这些组合物治疗各种疾病的方法。
• Compounds Which Modulate The CB2 Receptor
  申请人：BERRY Angela

  公开号：US20110130431A1

  公开（公告）日：2011-06-02

  Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

  公式(I)的化合物已被披露。根据本发明，这些化合物能够与CB2受体结合并作为激动剂、拮抗剂或反向激动剂，对治疗炎症具有用处。其中那些作为激动剂的化合物还可用于治疗疼痛。
• Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
  申请人：HADIDA-RUAH Sara Sabina

  公开号：US20140171427A1

  公开（公告）日：2014-06-19

  The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及杂环色烯-螺环哌啶酰胺，其可用作离子通道抑制剂。本发明还提供了包含该发明化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病的方法。
• BENZOXAZINES AS MODULATORS OF ION CHANNELS
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：US20140309220A1

  公开（公告）日：2014-10-16

  The invention relates to benzoxazines useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及苯并噁唑，其可用作离子通道的抑制剂。本发明还提供了包含本发明化合物的药学上可接受的组合物，并提供了使用这些组合物治疗各种疾病的方法。