(αR)-1-[(1-methylethoxy)carbonyl]-α-[[[(4-ethoxyphenyl)-2-thienyl]sulfonyl]-N-methyl-amino]-4-piperidineacetic acid | 458560-16-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (αR)-1-[(1-methylethoxy)carbonyl]-α-[[[(4-ethoxyphenyl)-2-thienyl]sulfonyl]-N-methyl-amino]-4-piperidineacetic acid
• 英文别名: (2R)-2-[[5-(4-ethoxyphenyl)thiophen-2-yl]sulfonyl-methylamino]-2-(1-propan-2-yloxycarbonylpiperidin-4-yl)acetic acid
• CAS: 458560-16-2
• 化学式: C₂₄H₃₂N₂O₇S₂
• 分子量: 524.659
• InChiKey: FXLZFVYGMZOLFP-JOCHJYFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  150
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• AZACYCLOALKYL SUBSTITUTED ACETIC ACID DERIVATIVES FOR USE AS MMP INHIBITORS
  申请人：Novartis AG

  公开号：EP1373262B1

  公开（公告）日：2010-05-12
• [EN] CERTAIN AZACYCLOALKYL SUBSTITUTED ACETIC ACID DERIVATIVES<br/>[FR] DERIVES D'ACIDE ACETIQUE SUBSTITUES AZACYCLOALKYLE
  申请人：NOVARTIS AG

  公开号：WO2002072577A2

  公开（公告）日：2002-09-19

  Compounds of the formula (I) wherein R represents OH or NHOH; R1 represents hydrogen, optionally substituted lower alkyl, aryl-lower alkyl, cycloalkyl-lower alkyl, or acyl derived from a carboxylic acid, from a carbonic acid, from a carbamic acid of from a sulfonic acid; R2 represents biarylsulfonyl or aryloxyarylsufonyl; R3 represents hydrogen, optionally substituted lower alkyl, aryl-lower alkyl, cycloalkyl-lower alkyl or acyl derived from a carboxylic acid, from a carbonic acid or form a carbamic acid; R4 and R5 represent independently hydrogen, lower alkyl, lower alkoxycarbonyl, aryl-lower alkyl or cycloalkyl-lower alkyl; m is zero, 1, 2 or 3; pharmaceutically acceptable prodrug derivatives thereof; pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds; and their use for inhibiting matrix degrading metalloproteinases and preventing or treating matrix metalloproteinase dependent conditions in mammals.