(1S,2S,3R,4R)-3-{6-chloro-2-{2-methoxy-4-(1-methylpiperidin-4-yl)phenyl}-3H-imidazo[4,5-b]pyridin-7-ylamino}bicyclo[2.2.1]hept-5-ene-2-carboxamide | 1449503-32-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (1S,2S,3R,4R)-3-{6-chloro-2-{2-methoxy-4-(1-methylpiperidin-4-yl)phenyl}-3H-imidazo[4,5-b]pyridin-7-ylamino}bicyclo[2.2.1]hept-5-ene-2-carboxamide
• 英文别名: (1S,2S,3R,4R)-3-{6-Chloro-2-[2-methoxy-4-(1-methyl-piperidin-4-yl)-phenyl]-3H-imidazo[4,5-b]pyridin-7-ylamino}-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide；(1S,2S,3R,4R)-3-[[6-chloro-2-[2-methoxy-4-(1-methylpiperidin-4-yl)phenyl]-1H-imidazo[4,5-b]pyridin-7-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide
• CAS: 1449503-32-5
• 化学式: C₂₇H₃₁ClN₆O₂
• 分子量: 507.035
• InChiKey: HUZWHOOJCHZEGN-XKPGHWPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (1S,2S,3R,4R)-3-(2,3-diamino-5-chloropyridin-4-ylamino)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide 、 2-Methoxy-4-(1-methyl-piperidin-4-yl)-benzaldehyde 以to produce 106 mg (49%) of the title compound的产率得到(1S,2S,3R,4R)-3-{6-chloro-2-{2-methoxy-4-(1-methylpiperidin-4-yl)phenyl}-3H-imidazo[4,5-b]pyridin-7-ylamino}bicyclo[2.2.1]hept-5-ene-2-carboxamide
  参考文献：
  名称：

  Imidazo[4,5-b]pyridine Derivatives as ALK and JAK Modulators for the Treatment of Proliferative Disorders

  摘要：

  本申请涉及公式I所定义的化合物和/或其盐。本申请还涉及使用这些化合物和/或其盐的组合物和方法。公式I的化合物可用作ALK和JAK调节剂，用于治疗增生性疾病。

  公开号：

  US20140350011A1

文献信息

• Imidazo[4,5-b]pyridine derivatives as ALK and JAK modulators for the treatment of proliferative disorders
  申请人：Cephalon, Inc.

  公开号：US09238656B2

  公开（公告）日：2016-01-19

  This application relates to compounds of the Formula I as defined herein, and/or salts thereof. This application further relates to compositions and methods of using these compounds and/or salts thereof. The compounds of Formula I are useful as ALK and JAK modulators for the treatment of proliferative disorders.

  本申请涉及公式I所定义的化合物及/或其盐。本申请还涉及使用这些化合物和/或其盐的组合物和方法。公式I的化合物可用作ALK和JAK调节剂，用于治疗增殖性疾病。
• IMIDAZO [4, 5 - B]PYRIDINE DERIVATIVES AS ALK AND JAK MODULATORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
  申请人：Cephalon, Inc.

  公开号：EP2809671B1

  公开（公告）日：2016-01-13
• US9238656B2
  申请人：——

  公开号：US9238656B2

  公开（公告）日：2016-01-19