5-(2,5-difluorophenyl)-N-methyl-N-(1-methylpiperidin-4-yl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrothiochromene]-3-carboxamide | 1146209-37-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫铬烷
• 英文名称: 5-(2,5-difluorophenyl)-N-methyl-N-(1-methylpiperidin-4-yl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrothiochromene]-3-carboxamide
• CAS: 1146209-37-1
• 化学式: C₂₄H₂₆F₂N₄OS₂
• 分子量: 488.625
• InChiKey: YCPNYZGANUQSQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  33
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  89.8
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Sequential Administration of Chemotherapeutic Agents for Treatment of Cancer
  申请人：Wang Yaolin

  公开号：US20110129456A1

  公开（公告）日：2011-06-02

  The present invention relates to the sequential administration of a cytotoxic agent followed by an IGF1R antagonist (e.g., an antibody) for the treatment of hyperproliferative disorders including cancer.

  本发明涉及采用细胞毒性药物后接IGF1R拮抗剂（例如抗体）的顺序治疗高增殖性疾病，包括癌症。
• COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY
  申请人：Siddiqui M. Arshad

  公开号：US20110123435A1

  公开（公告）日：2011-05-26

  The present invention relates to compounds of Formula (I), below, (wherein X, R1, R2, R3, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity. Formula I
• US8796460B2
  申请人：——

  公开号：US8796460B2

  公开（公告）日：2014-08-05
• [EN] FULLY HUMAN ANTI-VEGF ANTIBODIES AND METHODS OF USING<br/>[FR] ANTICORPS ANTI-VEGF ENTIÈREMENT HUMAINS ET MÉTHODES D'UTILISATION DE CEUX-CI
  申请人：SCHERING CORP

  公开号：WO2010124009A2

  公开（公告）日：2010-10-28

  Disclosed herein are fully human antibodies and antigen-binding fragments thereof that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling. The antibodies and antigen- binding fragments disclosed herein may be used, for example, to treat angiogenesis and conditions associated with angiogenesis both in vivo and in vitro.