3-Ethyl-6-i-propyl-s-tetrazin | 34753-07-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四嗪
• 英文名称: 3-Ethyl-6-i-propyl-s-tetrazin
• 英文别名: 3-ethyl-6-isopropyl-[1,2,4,5]tetrazine；3-Ethyl-6-propan-2-yl-1,2,4,5-tetrazine
• CAS: 34753-07-6
• 化学式: C₇H₁₂N₄
• 分子量: 152.199
• InChiKey: HKCGTEHSPMTKMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• HEMIASTERLIN DERIVATIVES FOR CONJUGATION AND THERAPY
  申请人：SUTRO BIOPHARMA, INC.

  公开号：US20210198314A1

  公开（公告）日：2021-07-01

  Provided herein are hemiasterlin derivatives, conjugates thereof, compositions comprising the derivatives or conjugates thereof, methods of producing the derivatives and conjugates thereof, and methods of using the derivatives, conjugates, and compositions for the treatment of cell proliferation. The derivatives, conjugates, and compositions are useful in methods of treatment and prevention of cell proliferation and cancer, methods of detection of cell proliferation and cancer, and methods of diagnosis of cell proliferation and cancer. In an embodiment, the hemiasterlin derivatives are according to Formula 1000: or a pharmaceutically acceptable salt, solvate, or tautomer thereof, wherein Ar, L, W 1 , W 4 , W 5 , SG, and R are as described herein.