3-Azabicyclo[4.1.0]heptane-3-carboxylic acid, 1-(3-methyl-1,2,4-oxadiazol-5-yl)-, 1,1-dimethylethyl ester | 1314018-41-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-Azabicyclo[4.1.0]heptane-3-carboxylic acid, 1-(3-methyl-1,2,4-oxadiazol-5-yl)-, 1,1-dimethylethyl ester
• 英文别名: tert-butyl 1-(3-methyl-1,2,4-oxadiazol-5-yl)-3-azabicyclo[4.1.0]heptane-3-carboxylate
• CAS: 1314018-41-1
• 化学式: C₁₄H₂₁N₃O₃
• 分子量: 279.339
• InChiKey: ZQHZIWGLXAGTPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  68.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-Azabicyclo[4.1.0]heptane-3-carboxylic acid, 1-(3-methyl-1,2,4-oxadiazol-5-yl)-, 1,1-dimethylethyl ester 在 盐酸 作用下， 以 乙醇 为溶剂， 以91%的产率得到5-(3-azabicyclo[4.1.0]heptan-1-yl)-3-methyl-1,2,4-oxadiazole hydrochloride
  参考文献：
  名称：

  [EN] COMPOUNDS AND COMPOSITIONS FOR COGNITION-ENHANCEMENT, METHODS OF MAKING, AND METHODS OF TREATING
  [FR] COMPOSÉS ET COMPOSITIONS POUR L'AMÉLIORATION DE LA COGNITION, LEURS PROCÉDÉS DE FABRICATION, ET MÉTHODES DE TRAITEMENT

  摘要：

  揭示了包括噻唑二唑衍生物在内的肌碱激动剂化合物，以及其组合物和制剂。还揭示了合成这种噻唑二唑化合物的方法。进一步揭示了使用这些肌碱激动剂或其药学适宜形式来增强认知功能的治疗方法。

  公开号：

  WO2011085406A1

文献信息

• COMPOUNDS AND COMPOSITIONS FOR COGNITION-ENHANCEMENT, METHODS OF MAKING, AND METHODS OF TREATING
  申请人：Hendrickson Michael L.

  公开号：US20110263613A1

  公开（公告）日：2011-10-27

  Disclosed are muscarinic agonist compounds including oxadiazole derivatives, compositions and preparations thereof. Also disclosed are methods of synthesizing such oxadiazole compounds. Further disclosed are methods for treating a subject with said muscarinic agonists or a pharmaceutically suitable form thereof to enhance cognitive function.

  本发明涉及包括氧代噻唑衍生物的肌肉型受体激动剂化合物，以及其组成物和制备方法。本发明还涉及合成此类氧代噻唑化合物的方法。进一步揭示了使用所述肌肉型受体激动剂或其药学适宜形式治疗受试者以增强认知功能的方法。
• Cognition Enhancing Compounds and Compositions, Methods of Making, and Methods of Treating
  申请人：Mithridion, Inc.

  公开号：US20130274299A1

  公开（公告）日：2013-10-17

  The invention relates generally to muscarinic agonists, which are useful for stimulating muscarine receptors, and treating cognitive disorders. Included among the muscarinic agonists disclosed herein are oxadiazole derivatives, compositions, and preparations thereof. Methods of synthesizing oxadiazole compounds also are provided. This disclosure also relates in part to compositions for enhancing cognitive function in subjects such as humans, the compositions comprising a muscarinic agonist or a pharmaceutically suitable form thereof. This disclosure relates in part to methods of treating animals such as humans by administering such compositions.

  本发明涉及肌肉碱受体激动剂，其可用于刺激肌肉碱受体和治疗认知障碍。本文所披露的肌肉碱受体激动剂包括噁唑烷衍生物、组合物及其制备。还提供了合成噁唑烷化合物的方法。本公开还涉及用于增强人类等受试者认知功能的组合物，该组合物包括肌肉碱受体激动剂或其药学适宜形式。本公开还涉及通过给予该类组合物治疗动物，如人类的方法。
• Compounds and Compositions for Cognition-Enhancement, Methods of Making, and Methods of Treating
  申请人：NeuroSolis, Inc.

  公开号：US20150099765A1

  公开（公告）日：2015-04-09

  Disclosed are muscarinic agonist compounds including oxadiazole derivatives, compositions and preparations thereof. Also disclosed are methods of synthesizing such oxadiazole compounds. Further disclosed are methods for treating a subject with said muscarinic agonists or a pharmaceutically suitable form thereof to enhance cognitive function.

  本发明涉及包括噁唑烷衍生物在内的毒蕈碱受体激动剂化合物，以及其组合物和制备方法。本发明还涉及合成这种噁唑烷化合物的方法。本发明还涉及使用所述毒蕈碱受体激动剂或其药学适宜形式来增强认知功能的方法。
• US8853219B2
  申请人：——

  公开号：US8853219B2

  公开（公告）日：2014-10-07
• US9174972B2
  申请人：——

  公开号：US9174972B2

  公开（公告）日：2015-11-03