1-(But-3-yn-1-yl)piperidin-4-amine dihydrochloride | 1334148-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(But-3-yn-1-yl)piperidin-4-amine dihydrochloride
• 英文别名: 1-but-3-ynylpiperidin-4-amine;dihydrochloride
• CAS: 1334148-24-1
• 化学式: C9H18Cl2N2
• mdl: MFCD19982525
• 分子量: 225.16
• InChiKey: SRKZLBUKVUJZPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.08
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.777
• 拓扑面积：
  29.3
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• TIACUMICIN DERIVATIVES AND THEIR USE AS ANTIBIOTICS
  申请人：Universität Zürich

  公开号：EP3508492A1

  公开（公告）日：2019-07-10

  The invention relates to a compound according to formula (1) wherein R1 to R4 and X are independently from each other a small functional group and R5 is -OH, or -O-Ln-Rap-Rbq-Lt-Rar-Rbs-Re, -O-Ln-Rbq-Rd-Lt-Rbs-Re with L being an alkyl linker, Ra being carbonyl, carboxyl or carboxamide, Rb being a cyclic moiety, Rd being a polyether linker and Re being a small functional end group, fluorescent dye or antibiotic with the proviso that the compound is not fidaxomicin. Furthermore, the invention relates to the use of the compound in the treatment of disease and the use in treating infections and/or bacterial infections caused by drug resistant bacteria.

  该发明涉及一种符合以下式（1）的化合物，其中R1至R4和X彼此独立地是小的功能基团，R5是-OH，或者-O-Ln-Rap-Rbq-Lt-Rar-Rbs-Re，-O-Ln-Rbq-Rd-Lt-Rbs-Re，其中L是烷基连接物，Ra是酰基，羧基或羧酰胺，Rb是环状基团，Rd是聚醚连接物，Re是小的功能末端基团，荧光染料或抗生素，但该化合物不是fidaxomicin。此外，该发明涉及该化合物在治疗疾病中的应用，以及在治疗由耐药细菌引起的感染和/或细菌感染中的应用。
• [EN] TIACUMICIN DERIVATIVES AND THEIR USE AS ANTIBIOTICS<br/>[FR] DÉRIVÉS DE TIACUMICINE ET LEUR UTILISATION EN TANT QU'ANTIBIOTIQUES
  申请人：UNIV ZUERICH

  公开号：WO2019135010A1

  公开（公告）日：2019-07-11

  The invention relates to a compound according to formula (1), wherein R1 to R4 and X are independently from each other a small functional group and R5 is -OH, or a moiety consisting of specific combinations of -L-, -Ra-, -Rb-, -Rd- and Re with L being an alkyl linker, Ra being carbonyl, carboxyl or carboxamide, Rb being a cyclic moiety, Rd being a polyether linker and Re being a small functional end group, fluorescent dye or antibiotic with the proviso that the compound is not fidaxomicin. Furthermore, the invention relates to the use of the compound in the treatment of disease and the use in treating infections and/or bacterial infections caused by drug resistant bacteria.