(4-cyclohexyl-piperazin-1-yl)-(4-piperidin-1-ylmethyl-phenyl)-methanone | 686721-21-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (4-cyclohexyl-piperazin-1-yl)-(4-piperidin-1-ylmethyl-phenyl)-methanone
• 英文别名: (4-Cyclohexylpiperazin-1-yl)-[4-(piperidin-1-ylmethyl)phenyl]methanone
• CAS: 686721-21-1
• 化学式: C₂₃H₃₅N₃O
• 分子量: 369.55
• InChiKey: CVRHIQNRTHGXBL-UHFFFAOYSA-N

物化性质

• 沸点：
  514.6±50.0 °C(Predicted)
• 密度：
  1.112±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  26.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES<br/>[FR] BENZAMIDES ET BENZTHIOAMIDES PIPERAZINYLE ET DIAZEPANYLE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2004037801A1

  公开（公告）日：2004-05-06

  Substituted piperazinyl and diazepanyl benzamides and benzthioamides of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.

  公式（I）的替代哌嗪基和二氮杂环己基苯甲酰胺和苯硫代酰胺，含有它们的组合物，以及制备和使用它们来治疗组胺介导的疾病的方法。
• Piperazinyl and diazapanyl benzamides and benzthioamides
  申请人：——

  公开号：US20040110746A1

  公开（公告）日：2004-06-10

  Substituted piperazinyl and diazepanyl benzamides and benzthioamides of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.

  公式（I）中的替代哌嗪基和二氮杂环巴豆酰胺和苯硫酰胺，包含它们的组合物以及制备和使用它们治疗组胺介导的疾病的方法。
• PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES
  申请人：Apodaca L. Richard

  公开号：US20080056991A1

  公开（公告）日：2008-03-06

  Substituted piperazinyl and diazepanyl benzamides and benzthioamides of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.

  本发明涉及公式（I）的替代哌嗪基和二氮杂环基苯甲酰胺和苯硫酰胺，包含它们的组合物以及使用它们治疗组胺介导的疾病的方法。
• NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES
  申请人：Mani S. Neelakandha

  公开号：US20070197508A1

  公开（公告）日：2007-08-23

  The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides, useful for the treatment of disorders and conditions mediated by the histamine receptor.

  本发明涉及一种新型制备取代哌嗪基和二氮杂环巴豆酰胺的方法，可用于治疗组织胺受体介导的疾病和病况。
• PROCESS FOR THE PREPARATION OF PIPERAZINYL AND DIAZEPANYL BENZAMIDE DERIVATIVES
  申请人：Choudhury Anusuya

  公开号：US20080171870A1

  公开（公告）日：2008-07-17

  The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.

  本发明涉及一种新颖的制备哌嗪基和二氮平基苯甲酰胺衍生物的方法，用于治疗由组胺受体介导的疾病和病况，优选为H3受体。