[SnPh3(C5Me4SiMe3)] | 1208258-45-0

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: [SnPh3(C5Me4SiMe3)]
• 英文别名: Trimethyl-(2,3,4,5-tetramethyl-1-triphenylstannylcyclopenta-2,4-dien-1-yl)silane
• CAS: 1208258-45-0
• 化学式: C₃₀H₃₆SiSn
• 分子量: 543.411
• InChiKey: ILEYWFHLYLWBPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.46
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  lithium (trimethylsilyl)tetramethylcyclopentadienide 、 三苯基氯化锡 以 四氢呋喃 为溶剂， 以77%的产率得到[SnPh3(C5Me4SiMe3)]
  参考文献：
  名称：

  Cyclopentadienyltin(IV) derivatives: Synthesis, characterization and study of their cytotoxic activities

  摘要：

  The organotin compounds. [SnPh3(C5H4R)] (R = Bu' (1), CMe2(CH2CH2CH=CH2) (2)) and [SnPh3(C5Me4R)] (R = H (3), SiMe3 (4)), were prepared by the reaction of SnPh3Cl with the lithium derivative of the corresponding cyclopentadiene. 1-4 have been characterized by multinuclear NMR spectroscopy (H-1, C-13{H-1} and Sn-119{H-1)). In addition. the molecular structures of 1, 2 and 4 were determined by single-crystal Xray diffraction studies. The cytotoxic activity of the organotin(IV) complexes (1-4) was tested against human tumour cell lines 8505C anaplastic thyroid cancer, A253 head and neck turnout. A549 lung carcinoma, A2780 ovarian cancer, DLD-1 colon carcinoma. Compounds 1-4 present higher activities than cisplatin in all the studied cells. The highest sensitivity of the synthesized tin(IV) complexes was observed against A2780 ovarian cancer and DLD-1 colon carcinoma. Complex 3 presents the highest cytotoxic activity of all the studied complexes in all the cancer cells, with IC50 values from 0.037 to 0.085 mu M, however, its trimethylsilyl-substituted analogue (4), showed the lowest activity against all the studied cells with IC50 values from 0.163 to 0.351 mu M. Complexes 1 and 2 presented very similar activities on all the cancer cells (IC50 values from 0.044 to 0.119 mu M). (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2009.05.056