1-[1,1-bis(4-methoxyphenyl)ethyl]-4-[2-(4-methoxyphenyl)propan-2-yl]benzene | 1153984-17-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-[1,1-bis(4-methoxyphenyl)ethyl]-4-[2-(4-methoxyphenyl)propan-2-yl]benzene
• 英文别名: 1-[1,1-Bis(4-methoxyphenyl)ethyl]-4-[1-(4-methoxyphenyl)-1-methyl-ethyl]benzene
• CAS: 1153984-17-8
• 化学式: C₃₂H₃₄O₃
• 分子量: 466.62
• InChiKey: LXOJOGJEPJOCNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  α,α,α'-三(4-羟苯基)-1-乙基-4-异丙苯 、 碘甲烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 24.0h， 以14%的产率得到1-[1,1-bis(4-methoxyphenyl)ethyl]-4-[2-(4-methoxyphenyl)propan-2-yl]benzene
  参考文献：
  名称：

  Structure-Based Discovery of Triphenylmethane Derivatives as Inhibitors of Hepatitis C Virus Helicase

  摘要：

  Hepatitis C virus nonstructural protein 3 (HCV NS3) helicase is believed to be essential for viral replication and has become an attractive target for the development of antiviral drugs. A fluorescence resonant energy transfer helicase assay was established for fast screening of putative inhibitors selected from virtual screening using the program DOCK. Soluble blue HT (1) was first identified as a novel HCV helicase inhibitor. Crystal structure of the NS3 helicase in complex with soluble blue HT shows that the inhibitor bears a significantly higher binding affinity mainly through a 4-sulfonatophenylaminophenyl group, and this is consistent with the activity assay. Subsequently, fragment-based searches were utilized to identify triphenylmethane derivatives for more potent inhibitors. Lead optimization resulted in a 3-bromo-4-hydroxyl substituted derivative 12 with an EC50 value of 2.72 mu M to Ava.5/Huh-7 cells and a lower cytotoxicity to parental Huh-7 cells (CC50 = 10.5 mu M), and it indeed suppressed HCV replication in the HCV replicon cells. Therefore, these inhibitors with structural novelty may serve as a useful scaffold for the discovery of new HCV NS3 helicase inhibitors.

  DOI：

  10.1021/jm8011905

文献信息

• PHOTOSENSITIVE RESIN COMPOSITION, METHOD FOR PRODUCING HEAT-RESISTANT RESIN FILM AND DISPLAY DEVICE
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20150301453A1

  公开（公告）日：2015-10-22

  The present invention provides a photosensitive resin composition which uses a polyimide precursor that has excellent solubility in organic solvents and is capable of reducing the viscosity of a resin composition obtained therefrom. The solution according to the present invention is a photosensitive resin composition which contains: an aromatic amide resin that has, as a main repeating unit, a specific structure having an amide group, a trifluoromethyl group and an aromatic ring; (b) a sensitizer; and (c) a solvent.
• POLYMERS OF MALEIMIDE AND CYCLOOLEFINIC MONOMERS AS PERMANENT DIELECTRIC MATERIALS
  申请人：PROMERUS, LLC

  公开号：US20160326292A1

  公开（公告）日：2016-11-10

  Various cycloolefinic/maleic anhydride/maleimide polymers and compositions thereof useful for forming self-imageable films encompassing such polymers are disclosed. Such polymers encompass norbornene-type repeating units, maleimide repeat units and maleic anhydride-type repeating units where at least some of such maleic anhydride-type repeating units have been ring-opened. The films formed from such polymer compositions provide self imageable, low-k, thermally stable layers for use in microelectronic and optoelectronic devices.
• ORGANIC EL DISPLAY DEVICE
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20170293224A1

  公开（公告）日：2017-10-12

  An object of the present invention is to provide an organic EL display device which causes neither decrease in emission luminance nor pixel shrinkage and is excellent in long-term reliability. The present invention is directed to an organic EL display device including an insulating layer formed on a first electrode of the organic EL display device and constituted of a cured film obtained from a positive type photosensitive resin composition containing (A) an alkali-soluble resin, (B) an o-quinonediazide compound and (C) an organic solvent, wherein the mole ratio S/C obtained when a section of the cured film is measured is greater than or equal to 0.003 and less than or equal to 0.008.
• ORGANIC EL DISPLAY DEVICE AND METHOD FOR MANUFACTURING SAME
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20180019290A1

  公开（公告）日：2018-01-18

  The purpose is to provide an organic EL display device which has good sensitivity and is free from the occurrence of luminance decrease or pixel shrinkage, thereby having excellent long-term reliability. In order to achieve the above-described purpose, provided is the following configuration. Namely, an organic EL display device wherein an insulating layer formed on a first electrode is a cured film obtained by curing a photosensitive resin composition; and the residual amount of acid anhydrides contained in the cured film is from 0.003 to 0.04 (inclusive) when the residual amount of aromatic rings contained in the cured film is taken as 1 (the reference value).
• PHOTOSENSITIVE RESIN COMPOSITION
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20180039174A1

  公开（公告）日：2018-02-08

  Regarding cured pattern films for semiconductor apparatuses, the present invention provides a photosensitive resin composition that is high in sensitivity and able to realize improved contact between a cured pattern film and metal wiring after a reflow process. The photosensitive resin composition includes an alkali-soluble resin which contains at least one selected from the group consisting of a resin (a-1) which contains, as primary component, a structure as represented by the undermentioned general formula (1), polyimides (a-2) and copolymers thereof, and a compound (c) which contains, as primary component, a structure as represented by the undermentioned general formula (2). (In general formula (1), R 1 and R 2 may be identical to or different from each other and each represent a divalent to octavalent organic group having 2 or more carbon atoms; R 3 and R 4 may be identical to or different from each other and each represent either a hydrogen atom or an organic group having 1 to 20 carbon atoms; n is an integer of 10 to 100,000; m and f are independently an integer of 0 to 2; p and q are independently an integer of 0 to 4; and m+q≠0 and p+q≠0.) (In general formula (2), R 5 , R 6 , and R 7 may be identical to or different from each other and each represent either a hydrogen atom or a monovalent organic group having 1 or more carbon atoms, and at least one of R 5 , R 6 , and R 7 is a monovalent organic group having 1 or more carbon atoms.)