N-(3-Jod-2-propinyl)piperidin | 22024-14-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(3-Jod-2-propinyl)piperidin
• 英文别名: 1-Piperidino-3-iodo-2-propin；1-(3-Iodoprop-2-ynyl)piperidine
• CAS: 22024-14-2
• 化学式: C₈H₁₂IN
• 分子量: 249.094
• InChiKey: GCKMYTQAWAOFFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Halopropargylated cyclic quaternary ammonium compound as antimicrobial agents
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0539114A2

  公开（公告）日：1993-04-28

  Antimicrobial compounds of the formula wherein wherein    R is (C₁ -C₂₀) straight or branched alkyl, optionally substituted with one or more of hydroxy, halogen, (C₁-C₂₀)alkoxy, phenoxy or -C(=O)R¹ where R¹ is (C₁ -C₂₀) alkyl, (C₁-C₂₀)alkoxy, phenoxy or NHR² wherein R² is (C₁-C₆) alkyl or phenyl; or R is benzyl; phenethyl; cyanoethyl; 2-cyanoethyl; propargyl; or allyl;    X is halogen, phosphate, acetate, benzoate, citrate, tartrate, alkyl- or arylsulfonate, or alkylsulfate; and    represents a 3- to 7-membered ring that contains at least one nitrogen atom optionally substituted with one or more of (C₁-C₃)alkyl, halo or carboxyl, said ring optionally containing one or two heteroatoms in addition to said one nitrogen atom, being sulphur, oxygen, or a second nitrogen are disclosed. Processes for inhibiting microbial growth, and compositions suitable therefor.

  式中的抗菌化合物 其中 R 是 (C₁ -C₂₀) 直链或支链烷基，可任选被羟基、卤素、(C₁-C₂₀)烷氧基中的一个或多个取代、苯氧基或 -C(=O)R¹ 其中 R¹ 是 (C₁ -C₂₀) 烷基、(C₁-C₂₀)烷氧基、苯氧基或 NHR² 其中 R² 是 (C₁-C₆) 烷基或苯基；或 R 是苄基、苯乙基、氰乙基、2-氰乙基、丙炔基或烯丙基； X 是卤素、磷酸盐、醋酸盐、苯甲酸盐、柠檬酸盐、酒石酸盐、烷基或芳基磺酸盐或 烷基硫酸盐；以及 代表至少含有一个氮原子的 3 至 7 元环，该氮原子可选择被 (C₁-C₃)烷基、卤代或羧基中的一个或多个取代，所述环除了所述一个氮原子外，还可选择含有一个或两个杂原子，即硫、氧或第二个氮。 抑制微生物生长的工艺以及适用于该工艺的组合物。
• Fused pyrimidine compound or salt thereof
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US10807986B2

  公开（公告）日：2020-10-20

  The problem to be solved by the present invention is to provide a novel compound having RET inhibitory activity. The present invention also provides a pharmaceutical preparation that is useful for the prevention and/or treatment of RET-related diseases, particularly cancer, based on RET inhibitory activity. The present invention provides a compound represented by Formula (I): wherein A, R2, and X are as defined in the specification; or a salt thereof.

  本发明要解决的问题是提供一种具有 RET 抑制活性的新型化合物。本发明还提供了一种基于 RET 抑制活性的药物制剂，可用于预防和/或治疗 RET 相关疾病，特别是癌症。本发明提供了一种由式（I）表示的化合物： 其中 A、R2 和 X 如说明书中所定义；或其盐。
• NOVEL FUSED PYRIMIDINE COMPOUND OR SALT THEREOF
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US20190330214A1

  公开（公告）日：2019-10-31

  The problem to be solved by the present invention is to provide a novel compound having RET inhibitory activity. The present invention also provides a pharmaceutical preparation that is useful for the prevention and/or treatment of RET-related diseases, particularly cancer, based on RET inhibitory activity. The present invention provides a compound represented by Formula (I): wherein A, R 2 , and X are as defined in the specification; or a salt thereof.
• US5266567A
  申请人：——

  公开号：US5266567A

  公开（公告）日：1993-11-30
• US5354862A
  申请人：——

  公开号：US5354862A

  公开（公告）日：1994-10-11