tofacitinib | 384337-73-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tofacitinib
• 英文别名: 2-Hydroxy-1-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-ethanone；Pfe-pkis 34；2-hydroxy-1-[4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]ethanone
• CAS: 384337-73-9
• 化学式: C₁₅H₂₁N₅O₂
• 分子量: 303.364
• InChiKey: CCOHWQFOFWCBMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  85.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Pyrrolo[2,3-d]pyrimidine compounds
  申请人：——

  公开号：US20020068746A1

  公开（公告）日：2002-06-06

  A compound of the formula 1 wherein R 1 , R 2 and R 3 are as defined above, useful as inhibitors of protein kinases, such as the enzyme Janus Kinase 3.

  一种具有上述定义的R1、R2和R3的化合物，用作蛋白激酶抑制剂，例如酶Janus激酶3。
• Pyrrolo[2,3-D]pyrimidine compounds
  申请人：Blumenkopf A. Todd

  公开号：US20050197349A1

  公开（公告）日：2005-09-08

  A compound of the formula wherein R 1 , R 2 and R 3 are as defined above, useful as inhibitors of protein kinases, such as the enzyme Janus Kinase 3.

  一种化合物的公式，其中R1，R2和R3如上所定义，可用作蛋白激酶的抑制剂，例如酶Janus Kinase 3。
• PYRROLO¬2,3-D|PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS
  申请人：Pfizer Products Inc.

  公开号：EP1294724B1

  公开（公告）日：2006-04-19
• Pyrrolo[2,3-d]pyrimidine compounds as immunosuppressive agents
  申请人：Pfizer Products Incorporated

  公开号：EP1686130B1

  公开（公告）日：2009-02-18
• ANTI-TOFACITINIB ANTIBODIES AND USES THEREOF FOR DRUG MONITORING
  申请人：Pfizer Inc.

  公开号：US20150337054A1

  公开（公告）日：2015-11-26

  The invention provides selective tofacitinib antibodies, immunogenic tofacitinib conjugates that are useful as immunogenic molecules for the generation of antibodies specific for tofacitinib, along with methods for measuring the concentration of tofacitinib in a sample, processes for making the antibodies, and assays and kits for using the antibodies.