Rhythmol | 2089-46-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Rhythmol
• 英文别名: 4-(2-phenylpropan-2-yl)-2,6-bis(piperidin-1-ylmethyl)phenol;hydrobromide
• CAS: 2089-46-5
• 化学式: C27H39BrN2O
• 分子量: 487.5
• InChiKey: JOKZINNGAITBTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.27
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  26.7
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

文献信息

• METHODS AND SYSTEMS FOR DESIGNING AND/OR CHARACTERIZING SOLUBLE LIPIDATED LIGAND AGENTS
  申请人：TUFTS MEDICAL CENTER

  公开号：US20160052982A1

  公开（公告）日：2016-02-25

  The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.

  本申请提供了制备可溶性脂质化配体药剂的方法，包括配体实体和脂质实体，并在某些实施例中提供了这些组分的相关参数，从而使得能够适当选择组分来组装出针对任何感兴趣的靶点的活性药剂。
• [EN] PRODRUG COMPOSITIONS AND METHODS OF TREATMENT<br/>[FR] COMPOSITIONS DE PROMÉDICAMENT ET PROCÉDÉS DE TRAITEMENT
  申请人：AQUESTIVE THERAPEUTICS INC

  公开号：WO2021087359A1

  公开（公告）日：2021-05-06

  Pharmaceutical compositions include a prodrug of epinephrine are described.

  药物组合物包括表述的肾上腺素前药。
• Pyrrole Derivatives As Pharmaceutical Agents
  申请人：Canne Bannen Lynne

  公开号：US20080234270A1

  公开（公告）日：2008-09-25

  Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.

  提供了用于调节受体活性的化合物、组合物和方法。特别提供了用于调节受体活性的化合物和组合物，以及用于治疗、预防或改善与受体活性直接或间接相关的一种或多种疾病或紊乱的症状的方法。
• Apparatus And Methods For Delivering A Plurality Of Medicaments For Management Of Co-Morbid Diseases, Illnesses Or Conditions
  申请人：MILLER Frederick H.

  公开号：US20100221321A1

  公开（公告）日：2010-09-02

  A method and apparatus for delivering a plurality of medicaments in a single delivery vehicle for the management of co-morbid diseases, illnesses and conditions. The present invention provides a novel delivery process for many medicaments. Medicaments may be encapsulated and stored separately within a larger capsule until the time of ingestion, consumption, or the like. Benefits of the present invention include maintaining separation of distinct ingredients within a single capsule and the capability to control the time release of multiple ingredients within the capsule.

  一种用于管理共病疾病、疾病和病状的多种药物在单一输送装置中输送的方法和装置。本发明提供了一种新颖的多种药物输送过程。药物可以被封装并分别存储在更大的胶囊中，直到摄入、消耗或类似的时间。本发明的好处包括在单个胶囊中保持不同成分的分离以及控制胶囊中多种成分的时间释放的能力。
• Bioavailability and improved delivery of alkaline pharmaceutical drugs
  申请人：Yu J. Ruey

  公开号：US20050196418A1

  公开（公告）日：2005-09-08

  Embodiments of the invention relate to a composition, a process of making the composition, and to the use of the composition. The compositions include a molecular complex formed between an alkaline pharmaceutical drug and at least one selected from a hydroxyacid, a polyhydroxy acid, a related acid, a lactone, or combinations thereof. The compositions provide improved bioavailability and improved delivery of the drug into the cutaneous tissues.

  本发明实施例涉及一种组合物、一种制备该组合物的方法以及该组合物的使用。该组合物包括碱性药物和至少选择自羟基酸、多羟基酸、相关酸、内酯或其组合形成的分子复合物。该组合物提供了改善的生物利用度和将药物传递到皮肤组织中的改进传递。