N-(o-Fluor-benzyl)-2-piperidon | 21269-96-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(o-Fluor-benzyl)-2-piperidon
• 英文别名: 1-(2-fluoro-benzyl)-piperidin-2-one；1-[(2-Fluorophenyl)methyl]piperidin-2-one
• CAS: 21269-96-5
• 化学式: C₁₂H₁₄FNO
• 分子量: 207.248
• InChiKey: FTDUYAJZMWVHMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• EP1485351A4
  申请人：——

  公开号：EP1485351A4

  公开（公告）日：2006-05-03
• PROCESS FOR THE MANUFACTURE OF OPTICALLY ACTIVE 3-SUBSTITUTED LACTAMS BY ASYMMETRIC HYDROGENATION OF 3-ALKYLIDENELACTAMS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1485351A2

  公开（公告）日：2004-12-15
• [EN] PROCESS FOR THE MANUFACTURE OF OPTICALLY ACTIVE 3-SUBSTITUTED LACTAMS BY ASYMMETRIC HYDROGENATION OF 3-ALKYLIDENELACTAMS<br/>[FR] PROCEDE DE FABRICATION DE LACTAMES SUBSTITUES EN POSITION 3 ET OPTIQUEMENT ACTIFS, PAR HYDROGENATION ASYMETRIQUE DE 3-ALKYLIDENELACTAMES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2003079975A2

  公开（公告）日：2003-10-02

  The present invention relates generally to processes for the efficient production optically active 3-substituted lactams of formula (I) [Insert chemical formula here] process, comprising: contacting a compound of formula (II): [Insert chemical formula here] with hydrogen under a suitable pressure in the presence of an iridium complex of the formula (R2)IrL+X- wherein L is a chelating diene, X is a non coordinating anion, and R2 is selected from . [Insert chemical formula here]