2-[(6-aminopyridin-3-yl)methyl]-5-{3-[(3-hydroxypyrrolidin-1-yl)carbonyl]phenyl}-3-mercaptopentanoic acid | 637300-83-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-[(6-aminopyridin-3-yl)methyl]-5-{3-[(3-hydroxypyrrolidin-1-yl)carbonyl]phenyl}-3-mercaptopentanoic acid
• 英文别名: 2-[(6-Aminopyridin-3-yl)methyl]-5-[3-(3-hydroxypyrrolidine-1-carbonyl)phenyl]-3-sulfanylpentanoic acid
• CAS: 637300-83-5
• 化学式: C₂₂H₂₇N₃O₄S
• 分子量: 429.54
• InChiKey: LQFDKFVQMLYWMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] 2,5-DISUBSTITUTED 3-MERCAPTOPENTANOIC ACID<br/>[FR] ACIDE 2,5-BISUBSTITUE 3-MERCAPTOPENTANOIQUE
  申请人：ASTRAZENECA AB

  公开号：WO2003106420A1

  公开（公告）日：2003-12-24

  The present invention concerns compounds of formula (I), and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the prevention and treatment of diseases where inhibition of carboxypeptidase U is beneficial. In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a pharmaceutically acceptable salt or solvate thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above.

  本发明涉及式(I)的化合物以及其药学上可接受的盐或溶剂，或这些盐的溶剂，这些化合物抑制羧肽酶U，因此可以用于预防和治疗抑制羧肽酶U有益的疾病。在进一步方面，本发明涉及用于治疗的本发明化合物；制备这些新化合物的过程；含有本发明化合物中至少一种，或其药学上可接受的盐或溶剂的制药组合物作为活性成分；以及将活性化合物用于制造上述医疗用途的药物。
• 2,5-disubstituted 3-mercaptopentanoic acid
  申请人：Polla Magnus

  公开号：US20050176780A1

  公开（公告）日：2005-08-11

  The present invention concerns compounds of formula (I), and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the prevention and treatment of diseases where inhibition of carboxypeptidase U is beneficial. In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a pharmaceutically acceptable salt or solvate thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above.

  本发明涉及式（I）的化合物，以及其药学上可接受的盐或溶剂，或该类盐的溶剂，这些化合物能够抑制羧肽酶U，因此可用于预防和治疗抑制羧肽酶U有益的疾病。在进一步方面，本发明涉及该发明的化合物用于治疗的用途；制备这种新化合物的过程；包含至少一种该发明化合物或其药学上可接受的盐或溶剂的药物组合物，作为活性成分；以及在制造上述医疗用途的药物中使用活性化合物。
• 2,5-DISUBSTITUTED 3-MERCAPTOPENTANOIC ACID
  申请人：AstraZeneca AB

  公开号：EP1532111A1

  公开（公告）日：2005-05-25
• US7572817B2
  申请人：——

  公开号：US7572817B2

  公开（公告）日：2009-08-11