1-(4-(2-fluoro-4-(5-fluoro-4-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)pyrimidin-2ylamino)phenoxy)piperidin-1-yl)ethanone | 1239595-03-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(4-(2-fluoro-4-(5-fluoro-4-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)pyrimidin-2ylamino)phenoxy)piperidin-1-yl)ethanone
• 英文别名: 1-[4-[2-Fluoro-4-[[5-fluoro-4-[(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]pyrimidin-2-yl]amino]phenoxy]piperidin-1-yl]ethanone
• CAS: 1239595-03-9
• 化学式: C₂₇H₃₈F₂N₆O₂
• 分子量: 516.635
• InChiKey: PHHDPSCSAAPVAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  82.6
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• PROTEIN KINASE C INHIBITORS AND USES THEREOF
  申请人：Singh Rajinder

  公开号：US20100204208A1

  公开（公告）日：2010-08-12

  This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

  这项披露涉及作为蛋白激酶C（PKC）抑制剂有用的化合物，因此可用于治疗通过PKC活性介导或维持的各种疾病和疾病。该披露还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和疾病的方法，制备这些化合物的过程以及在这些过程中有用的中间体。
• Protein Kinase C Inhibitors and Uses Thereof
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20130210810A1

  公开（公告）日：2013-08-15

  This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

  此披露涉及化合物，其可用作蛋白激酶C（PKC）的抑制剂，因此可用于治疗通过PKC的活动介导或维持的各种疾病和疾病。此披露还涉及包含这些化合物的制药组合物，使用这些化合物治疗各种疾病和疾病的方法，制备这些化合物和在这些过程中有用的中间体的过程。
• DERIVATIVES OF N2-(3-PYRIDYL OR PHENYL)-N4-(4-PIPERIDYL)-2,4-PYRIMIDINEDIAMINE USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE OR PROLIFERATIVE DISEASES
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP2389373B1

  公开（公告）日：2017-05-17
• US8377924B2
  申请人：——

  公开号：US8377924B2

  公开（公告）日：2013-02-19
• US9149475B2
  申请人：——

  公开号：US9149475B2

  公开（公告）日：2015-10-06