5'-O-(4,4'-dimethoxytrityl)-3-oxoperylene-1'-α-deoxyriboside | 667458-10-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5'-O-(4,4'-dimethoxytrityl)-3-oxoperylene-1'-α-deoxyriboside
• CAS: 667458-10-8
• 化学式: C₄₆H₃₈O₆
• 分子量: 686.804
• InChiKey: FVFTZQUVIDDMBQ-NTTVKKKKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.62
• 重原子数：
  52.0
• 可旋转键数：
  10.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  66.38
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  5'-O-(4,4'-dimethoxytrityl)-3-oxoperylene-1'-α-deoxyriboside 、 2-氰乙基N,N-二异丙基氯亚磷酰胺 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以88%的产率得到5'-O-(4,4'-dimethoxytrityl)-3-oxoperylene-1'-α-deoxyriboside-3'-O-(cyanoethyl-N,N-diisopropylamino)phosphoramidite
  参考文献：
  名称：

  Libraries of Composite Polyfluors Built from Fluorescent Deoxyribosides

  摘要：

  We report on a new class of water-soluble fluorescent molecules (polyfluors) that are composed of multiple individual fluorophores assembled on a DNA-like backbone. Four fluorophore deoxyribosides were synthesized, and these individual molecules were assembled into oligofluor strings on a DNA synthesizer. A library of 256 tetrafluors was generated by split and pool methods on polystyrene beads. Images of the library under a fluorescence microscope revealed at least 40-50 different hues and intensities. Selected tetrafluors were resynthesized in pure form in solution and displayed properties, such as large Stokes shifts, that individual fluorophores do not have.

  DOI：

  10.1021/ja027197a
• 作为产物：
  描述：

  3-溴芘 在 sodium methylate 、 N,N-二异丙基乙胺 作用下， 以 吡啶 、 甲醇 、 二氯甲烷 为溶剂， 反应 8.0h， 生成 5'-O-(4,4'-dimethoxytrityl)-3-oxoperylene-1'-α-deoxyriboside
  参考文献：
  名称：

  Libraries of Composite Polyfluors Built from Fluorescent Deoxyribosides

  摘要：

  We report on a new class of water-soluble fluorescent molecules (polyfluors) that are composed of multiple individual fluorophores assembled on a DNA-like backbone. Four fluorophore deoxyribosides were synthesized, and these individual molecules were assembled into oligofluor strings on a DNA synthesizer. A library of 256 tetrafluors was generated by split and pool methods on polystyrene beads. Images of the library under a fluorescence microscope revealed at least 40-50 different hues and intensities. Selected tetrafluors were resynthesized in pure form in solution and displayed properties, such as large Stokes shifts, that individual fluorophores do not have.

  DOI：

  10.1021/ja027197a