| 1616093-48-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 1616093-48-1；1627824-36-5
• 化学式: C₅₀H₅₆N₅O₁₁P
• 分子量: 933.995
• InChiKey: ZXPOTEYSOAAHAR-AFTRVLEUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.11
• 重原子数：
  67.0
• 可旋转键数：
  21.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  183.88
• 氢给体数：
  1.0
• 氢受体数：
  14.0

反应信息

• 作为产物：
  描述：

  2-氰乙基N,N-二异丙基氯亚磷酰胺 、 2'-O-(2-phthalimidoethyl)-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 、
  参考文献：
  名称：

  Kinetic study of the binding of triplex-forming oligonucleotides containing partial cationic modifications to double-stranded DNA

  摘要：

  Several triplex-forming oligonucleotides (TFOs) partially modified with 2'-O-(2-aminoethyl)- or 2'O-0(2-guanidinoethyl)-nucleotides were synthesized and their association rate constants (k(on)) with double-stranded DNA were estimated by UV spectrophotometry. Introduction of cationic modifications in the 5'-region of the TFOs significantly increased the k(on) values compared to that of natural TFO, while no enhancement in the rate of triplex DNA formation was observed when the modifications were in the middle and at the 3'-region. The k(on) value of a TFO with three adjacent cationic modifications at the 5'-region was found to be 3.4 times larger than that of a natural one. These results provide useful information for overcoming the inherent sluggishness of triplex DNA formation. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.05.031