{3-[(2R,4R,5R)-4-(4-methoxy-phenyl)-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-piperidin-2-yl]-2,2-dimethyl-propyl}-(tetrahydro-pyran-4-yl)-amine | 911706-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: {3-[(2R,4R,5R)-4-(4-methoxy-phenyl)-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-piperidin-2-yl]-2,2-dimethyl-propyl}-(tetrahydro-pyran-4-yl)-amine
• 英文别名: N-[3-[(2R,4R,5R)-4-(4-methoxyphenyl)-5-[[4-(3-methoxypropyl)-2,3-dihydro-1,4-benzoxazin-6-yl]methoxy]-1-(4-methylphenyl)sulfonylpiperidin-2-yl]-2,2-dimethylpropyl]oxan-4-amine
• CAS: 911706-92-8
• 化学式: C₄₂H₅₉N₃O₇S
• 分子量: 750.012
• InChiKey: VYITZMRFABVTGI-HKBSIIRGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  53
• 可旋转键数：
  16
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  3-[(2R,4R,5R)-4-(4-methoxy-phenyl)-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-piperidin-2-yl]-2,2-dimethyl-propionaldehyde 、 4-氨基四氢吡喃 生成 {3-[(2R,4R,5R)-4-(4-methoxy-phenyl)-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-piperidin-2-yl]-2,2-dimethyl-propyl}-(tetrahydro-pyran-4-yl)-amine
  参考文献：
  名称：

  Substituted piperidines

  摘要：

  公式（I）和（II）的取代哌啶，其取代基的定义在说明书中有解释。这些化合物特别适用于肾素抑制剂，并且具有高度的效力。

  公开号：

  US07687495B2

文献信息

• 2,4,5-Substituted Piperidines as Renin Inhibitors
  申请人：Herold Peter

  公开号：US20100029628A1

  公开（公告）日：2010-02-04

  SP-P2140 ATE-132—Abstract Novel substituted piperidines of the general formula (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent.

  SP-P2140 ATE-132——摘要描述了一般式（I）和（II）的新型取代哌啶化合物，其中取代基的定义在描述中详细说明。这些化合物特别适用于作为肾素抑制剂，并具有高度的效力。
• Substituted piperidines as inhibitors of beta-secretase, cathepsin D, plasmepsin II and/or HIV protease
  申请人：Speedel Experimenta AG

  公开号：EP1958634A2

  公开（公告）日：2008-08-20

  Use of compounds of the general formula (I) or (II) and pharmaceutically acceptable salt thereof, in which R, R1, R2, R3, R4, Q, W, X and Z, n and m have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibitors.

  通式(I)或(II)化合物的使用 及其药学上可接受的盐，其中 R、R1、R2、R3、R4、Q、W、X 和 Z、n 和 m 具有描述中详细说明的定义，可作为 β-分泌酶、Chepsin D、plasmepsin II 和/或 HIV 蛋白酶抑制剂。
• SUBSTITUTED PIPERIDINES
  申请人：Novartis AG

  公开号：EP1863803B1

  公开（公告）日：2010-09-01
• US7687495B2
  申请人：——

  公开号：US7687495B2

  公开（公告）日：2010-03-30
• [EN] NOVEL ANTIMICROBIALS<br/>[FR] NOUVEAUX AGENTS ANTIMICROBIENS
  申请人：PANACEA BIOTEC LTD

  公开号：WO2010058423A2

  公开（公告）日：2010-05-27

  The present invention relates to novel phenyl oxazolidinone compounds of formula I, their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of formula I or their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of formula I and methods of using them. The compounds of the present invention are useful as antimicrobial agents, effective against a number of aerobic and/or anaerobic Gram positive and/or Gram negative pathogens such as multi drug resistant species of Staphylococcus, Streptococcus, Enterococcus, Bacterioides,Clostridia, H. influenza, Moraxella, acid-fast organisms such as Mycobacterium tuberculosis as well as Linezolid resistant species of Staphylococcus and Enterococcus.