2,3-Dihydro-1-benzothiophen-3-amine | 1154342-11-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫铬烷
• 英文名称: 2,3-Dihydro-1-benzothiophen-3-amine
• CAS: 1154342-11-6
• 化学式: C₈H₉NS
• 分子量: 151.23
• InChiKey: DNIHSQRMUDUEQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A
  申请人：Abbott GmbH & Co.KG

  公开号：US20130116229A1

  公开（公告）日：2013-05-09

  The present invention relates to compounds which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.

  本发明涉及一类磷酸二酯酶10A抑制剂化合物，以及它们用于制造药物的用途，因此适用于治疗或控制从神经系统疾病和精神疾病中选择的医学疾病，改善与这些疾病相关的症状，并降低这些疾病的风险。
• Inhibitor compounds of phosphodiesterase type 10A
  申请人：AbbVie Deutschland GmbH & Co. KG

  公开号：US10308610B2

  公开（公告）日：2019-06-04

  The present invention relates to compounds which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders. wherein X1 is CH or N, X2 is C—R5 or N, Y is O or S, R1 is inter alia C2-C8-alkyl, C2-C8-alkenyl, C1-C4-fluoroalkyl, C3-C8-cycloalkyl, C5-C8-cycloalkyl carrying a fused benzene ring, or a moiety Z1—Ar1; R2 is a radical of the formula CR21R22R23 or phenyl or 5- or 6-membered hetaryl having 1, 2 or 3 heteroatoms as ring members which are selected from O, S and N, where phenyl and monocyclic hetaryl are unsubstituted or may carry 1, 2 or 3 identical or different substituents Ra, R3 is inter alia hydrogen, C1-C8-alkyl, C2-C8-alkenyl, C1-C4-fluoroalkyl, C3-C8-cycloalkyl, etc, or R2 and R3 together with the nitrogen atom, to which they are bound form an optionally substituted saturated 5- to 7-membered heterocyclic ring which, in addition to the nitrogen atom, may have 1 or 2 further heteroatoms or heteroatom containing groups selected from the group of O, N, S, SO and SO2; R4 is inter alia C1-C4-alkyl, C1-C4-fluoroalkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl or Z4—Ar4; R5 is inter alia hydrogen, halogen, C1-C4-alkyl, C1-C4-fluoroalkyl, C1-C4-alkoxy, C1-C4-fluoroalkoxy, —Z5—Ar5, —O—Z5—Ar5, etc; where Z1 to Z5, Ar1 to Ar5, Ra, R21, R22 and R23 are as defined in the claims.

  本发明涉及作为 10A 型磷酸二酯酶抑制剂的化合物及其用于制造药物的用途，因此这些化合物适用于治疗或控制选自神经系统疾病和精神疾病的内科疾病，改善与此类疾病相关的症状以及降低此类疾病的风险。 其中 X1 是 CH 或 N，X2 是 C-R5 或 N，Y 是 O 或 S、 R1 除其他外，是 C2-C8 烷基、C2-C8-烯基、C1-C4-氟烷基、C3-C8-环烷基、带有融合苯环的 C5-C8 环烷基或分子 Z1-Ar1； R2 是式 CR21R22R23 的基或苯基或具有 1、2 或 3 个杂原子作为环成员的 5 或 6 元 hetaryl，这些杂原子选自 O、S 和 N，其中苯基和单环 hetaryl 未被取代或可带有 1、2 或 3 个相同或不同的取代基 Ra、 R3 除其他外为氢、C1-C8-烷基、C2-C8-烯基、C1-C4-氟烷基、C3-C8-环烷基等，或 R2 和 R3 与它们所结合的氮原子一起形成一个任选取代的饱和 5-7 元杂环，除氮原子外，该杂环可再有 1 或 2 个杂原子或含杂原子的基团，这些基团选自 O、N、S、SO 和 SO2 组； R4 除其他外为 C1-C4 烷基、C1-C4-氟烷基、C3-C6-环烷基、C3-C6-环烷基-C1-C4-烷基或 Z4-Ar4； R5 除其他外为氢、卤素、C1-C4-烷基、C1-C4-氟烷基、C1-C4-烷氧基、C1-C4-氟烷氧基、-Z5-Ar5、-O-Z5-Ar5 等； 其中 Z1 至 Z5、Ar1 至 Ar5、Ra、R21、R22 和 R23 如权利要求中所定义。
• HETEROCYCLIC CARBOXAMIDES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE TYPE 10A
  申请人：Abbvie Deutschland GmbH & Co. KG

  公开号：EP2780324A1

  公开（公告）日：2014-09-24
• US9856220B2
  申请人：——

  公开号：US9856220B2

  公开（公告）日：2018-01-02
• [EN] PHTHALAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE PHTALAZINONE
  申请人：KUDOS PHARM LTD

  公开号：WO2008114023A2

  公开（公告）日：2008-09-25

  [EN] A compound of the formula (I) wherein: A and B together represent an optionally substituted, fused aromatic ring or an optionally substituted, fused cyclohexene ring; D is selected from: (i), where Y¹ is selected from CH and N, Y² is selected from CH and N, Y³ is selected from CH, CF and N and Y⁴ is selected from CH and N; (ii) where Y¹is selected from CH and N and Y² is selected from CH and N; (iii) and where Q is O or S; and (iv), where Q is O or S; and R^D is an optionally substituted C_5-20 aryl group, bound to D by a carbon-carbon bond.
  [FR] La présente invention concerne un composé de formule (I), dans laquelle : A et B représentent ensemble un cycle aromatique fusionné, facultativement substitué, ou un cycle cyclohexène fusionné, facultativement substitué; D est choisi parmi : (i), où Y¹ est choisi parmi CH et N, Y² est choisi parmi CH et N, Y³ est choisi parmi CH, CF et N et Y⁴ est choisi parmi CH et N; (ii) où Y¹ est choisi parmi CH et N et Y² est choisi parmi CH et N; (iii) et où Q est O ou S; et (iv), où Q est O ou S; et R^D est un groupe aryle en C_5-20 facultativement substitué, lié à D par une liaison carbone-carbone.