[1-(2,6-dimethylphenyl)pipenidin-3-yl]methanol | 955929-52-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [1-(2,6-dimethylphenyl)pipenidin-3-yl]methanol
• 英文别名: [1-(2,6-Dimethylphenyl)piperidin-3-yl]methanol
• CAS: 955929-52-9
• 化学式: C₁₄H₂₁NO
• 分子量: 219.327
• InChiKey: DTWGXVQJECXNMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  methyl 1-(2,6-dimethylphenyl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate 在 lithium aluminium tetrahydride 作用下， 反应 2.0h， 生成 [1-(2,6-dimethylphenyl)pipenidin-3-yl]methanol
  参考文献：
  名称：

  EP2011788

  摘要：

  公开号：

文献信息

• Oxadiazolidinedione compound
  申请人：Astellas Pharma Inc.

  公开号：US07968552B2

  公开（公告）日：2011-06-28

  A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the like, is provided. It was found that an oxadiazolidinedione compound which is characterized by the possession of a benzyl or the like substituent binding to the cyclic group via a linker at the 2-position of the oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof, has excellent GPR40 agonist action. In addition, since the oxadiazolidinedione compound of the present invention showed excellent insulin secretion promoting action and blood glucose level-lowering action, it is useful as an insulin secretion promoter or an agent for preventing/treating diabetes.

  提供了一种可用作药物的化合物，特别是胰岛素分泌促进剂或用于预防/治疗与GPR40相关的疾病，例如糖尿病等。发现一种噁唑烷二酮化合物，其特征在于在噁唑烷二酮环的2位通过连接基与环状基团结合的苄基或类似基团，或其药学上可接受的盐具有优异的GPR40激动剂作用。此外，由于本发明的噁唑烷二酮化合物显示出优异的胰岛素分泌促进作用和降低血糖水平的作用，因此它可用作胰岛素分泌促进剂或预防/治疗糖尿病的药物。
• Oxadiazolidinedione Compound
  申请人：Negoro Kenji

  公开号：US20090186909A1

  公开（公告）日：2009-07-23

  [Problem] A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the like, is provided. [Means for resolution] It was found that an oxadiazolidinedione compound which is characterized by the possession of a benzyl or the like substituent binding to the cyclic group via a linker at the 2-position of the oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof, has excellent GPR40 agonist action. In addition, since the oxadiazolidinedione compound of the present invention showed excellent insulin secretion promoting action and blood glucose level-lowering action, it is useful as an insulin secretion promoter or an agent for preventing/treating diabetes.

  【问题】提供一种可用作药物的化合物，特别是胰岛素分泌促进剂或用于预防/治疗涉及GPR40的疾病，如糖尿病等。 【解决方法】发现一种氧代唑烷二酮化合物，其特征在于在氧代唑烷二酮环的2位通过连接基与环上的苯甲基或类似取代基结合，或其药学上可接受的盐具有优异的GPR40激动剂作用。此外，由于本发明的氧代唑烷二酮化合物表现出良好的胰岛素分泌促进作用和降低血糖水平的作用，因此它可用作胰岛素分泌促进剂或预防/治疗糖尿病的药物。
• OXADIAZOLIDINEDIONE COMPOUND
  申请人：Astellas Pharma Inc.

  公开号：EP2011788A1

  公开（公告）日：2009-01-07

  [Problem] A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the like, is provided. [Means for resolution] It was found that an oxadiazolidinedione compound which is characterized by the possession of a benzyl or the like substituent binding to the cyclic group via a linker at the 2-position of the oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof, has excellent GPR40 agonist action. In addition, since the oxadiazolidinedione compound of the present invention showed excellent insulin secretion promoting action and blood glucose level-lowering action, it is useful as an insulin secretion promoter or an agent for preventing/treating diabetes.

  [问题]本发明提供了一种可用作药物的化合物，特别是胰岛素分泌促进剂或预防/治疗与 GPR40 有关的疾病（如糖尿病或类似疾病）的药物。 [解决方法]研究发现，一种噁二唑烷二酮化合物或其药学上可接受的盐具有优异的 GPR40 激动剂作用，该化合物的特点是在噁二唑烷二酮环的 2 位上通过连接物具有与环基结合的苄基或类似取代基。此外，由于本发明的噁二唑烷二酮化合物具有优异的促进胰岛素分泌作用和降低血糖作用，因此可用作胰岛素分泌促进剂或预防/治疗糖尿病的药物。
• CYCLIC AMIDE DERIVATIVE
  申请人：Mochida Pharmaceutical Co., Ltd.

  公开号：EP2703393A1

  公开（公告）日：2014-03-05

  [Problem] To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogues and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases. [Means of solving the problem] A compound of Formula (I): (where n is 0 to 2; p is 0 to 4; his 0 to 3; j is 0 to 3; k is 0 to 2; a ring B is an aryl group or a heteroaryl group; X is O, S, or -NR7-; J1 is -CR11aR11b- or -NR11c-; J2 is -CR12aR12b- or -NR12c-; and R1 to R12c are specific groups), a salt of the compound, or a solvate of the salt or the compound.

  问题 提供一种GPR40激活剂，其有效成分为具有GPR40激动剂作用的新型化合物、该化合物的盐、该盐或该化合物的溶液或类似物，特别是一种胰岛素促泌剂和糖尿病、肥胖症或其他疾病的预防和/或治疗剂。 [解决问题的方法］ 一种式（I）化合物： (其中 n 为 0 至 2；p 为 0 至 4；his 为 0 至 3；j 为 0 至 3；k 为 0 至 2；环 B 为芳基或杂芳基；X 为 O、S 或-NR7-；J1 为-CR11aR11b-或-NR11c-；J2 为-CR12aR12b-或-NR12c-；R1 至 R12c 为特定基团）、 该化合物的盐，或该盐或该化合物的溶液。
• US7968552B2
  申请人：——

  公开号：US7968552B2

  公开（公告）日：2011-06-28