硅酸钙

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱土金属氧阴离子化合物
• 中文名称: 硅酸钙
• 中文别名: 微孔硅酸钙；活性硅酸钙；无水硅酸钙；钙标样；有机金属钙
• 英文名称: dicalcium;silicate
• 化学式: Ca2O4Si
• 分子量: 172.24
• InChiKey: JHLNERQLKQQLRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.2
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

毒理性

• 致癌性证据

A4；不可分类为人类致癌物。/硅酸钙（合成无纤维）/

A4; Not classifiable as a human carcinogen. /Calcium silicate (synthetic nonfibrous)/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

对于人类来说，对滑石棉致癌性的证据不足。在实验动物中，对滑石棉致癌性的证据也不足。总体评估：滑石棉对人类的致癌性无法分类（第3组）。

There is inadequate evidence in humans for the carcinogenicity of wollastonite. There is inadequate evidence in experimental animals for the carcinogenicity of wollastonite. Overall evaluation: Wollastonite cannot be classifed as to its carcinogenicity to humans (Group 3).

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 暴露途径

暴露主要通过吸入发生。

Exposure mainly occurs via inhalation.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 暴露途径

吸入，皮肤和/或眼睛接触

inhalation, skin and/or eye contact

来源:The National Institute for Occupational Safety and Health (NIOSH)

毒理性

• 症状

眼睛、皮肤、上呼吸道刺激

irritation eyes, skin, upper respiratory system

来源:The National Institute for Occupational Safety and Health (NIOSH)

吸收、分配和排泄

这种物质可以通过吸入被身体吸收。

The substance can be absorbed into the body by inhalation.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  硅酸钙 、 对正丁氨基苯甲酸-2-(ω)-甲氧工-八乙氧基-乙酯 生成 Benzonatate calcium silicate
  参考文献：
  名称：

  BENZONATATE MODIFIED RELEASE SOLID TABLETS AND CAPSULES

  摘要：

  本发明涉及一种12小时抗咳改良释放固体片剂或胶囊，其包括苯佐卡因吸附剂在基质中，并含有足够量的一种或多种药学上可接受的改良释放pH独立物质，以为苯佐卡因提供12小时的改良释放特性。其中，在口腔中基本上不释放苯佐卡因，而在体外溶解试验中，苯佐卡因的释放在1小时内不超过25%。

  公开号：

  US20160008312A1
• 作为产物：
  描述：

  calcium;dinitrate 、 硅酸四乙酯 、 柠檬酸 、 硝酸铵 、 Azane;nitrate 、 在 硅酸钙 作用下， 以 乙醇 为溶剂， 以can get monocalcium silicate (CaSiO3), dicalcium silicate (Ca2SiO4) or calcium silicate (Ca3SiO5)的产率得到calcium dihydrogenorthosilicate
  参考文献：
  名称：

  Single step process for the synthesis of nanoparticles of ceramic oxide powders

  摘要：

  本发明涉及一种单步合成单一或多组分体系的相纯陶瓷氧化物纳米颗粒的方法，其中包括一个或多个金属离子。该方法包括制备一个溶液，其中包含所有所需的金属离子，其摩尔比例为化学计量比，通过在有机溶剂或水中溶解其相应的可溶性盐来完成，制备前驱体，调整系统中硝酸盐/氨含量，并加热系统。

  公开号：

  US20020110517A1
• 作为试剂：
  描述：

  3-(3,5-二叔丁基-4-羟基苯基)丙酸 、 硬脂酰胺MEA 、 邻二甲苯 在 tetrabutoxytitanium 硅酸钙 、 title compound 、 丙烯腈 作用下， 以 水 为溶剂， 反应 6.0h， 生成 2-stearamidoethyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
  参考文献：
  名称：

  Phenolic esteramide antioxidants

  摘要：

  具有新颖酚基取代的酰胺酸酯，作为抗氧化剂可用于保护有机物材料，如合成和天然橡胶、塑料和石油产品免受氧化降解的影响。

  公开号：

  US04305868A1

文献信息

• Coated/treated metal silicate absorbent particles
  申请人：Withiam C. Michael

  公开号：US20060171972A1

  公开（公告）日：2006-08-03

  Coated particles of metal (such as calcium) silicate that exhibit excellent odor neutralization and sebum absorption properties when present within certain cosmetic and/or personal care formulations and suspensions are provided. Uncoated calcium silicate exhibits a high pH level that may have a deleterious effect upon such cosmetic and/or personal care compositions, thereby rendering the overall composition ineffective for its intended purpose, particularly if the calcium silicate is present in its usual state at high loading levels. Alternatively, if certain materials present within personal care compositions exhibit a sufficiently low pH level, the effectiveness of such calcium silicates may be compromised as well. Such novel coated/treated calcium silicates thus permit high loadings of this beneficial odor neutralizing/sebum absorbing additive within cosmetic and/or personal care formulations without causing any appreciable instability issues or viscosity modification concerns or allow for coexistence with such low pH materials without any appreciable reduction in performance capabilities of the calcium silicates themselves. Certain personal care compositions comprising these novel coated calcium silicate particulates are encompassed within this invention as well.

  本发明提供了一种金属（如钙）硅酸盐的涂层颗粒，当其存在于某些化妆品和/或个人护理配方和悬浮液中时，表现出优异的气味中和和皮脂吸收性能。未涂层的硅酸钙表现出高pH值，可能对此类化妆品和/或个人护理组合物产生不良影响，从而使整个组合物对其预期用途无效，特别是如果硅酸钙以高负载水平存在于其通常状态中。或者，如果个人护理组合物中存在某些材料的pH值足够低，那么这种硅酸钙的有效性也可能会受到损害。这种新型涂层/处理的硅酸钙因此允许在化妆品和/或个人护理配方中高负载这种有益的气味中和/皮脂吸收添加剂，而不会引起任何明显的不稳定性问题或粘度修改问题，或者允许与这些低pH材料共存，而不会明显降低硅酸钙本身的性能能力。本发明还涵盖了包含这些新型涂层硅酸钙颗粒的某些个人护理组合物。
• Personal care compositions comprising coated/treated metal silicate absorbent particles
  申请人：Withiam C. Michael

  公开号：US20060171973A1

  公开（公告）日：2006-08-03

  Coated particles of metal (such as calcium) silicate that exhibit excellent odor neutralization and sebum absorption properties when present within certain cosmetic and/or personal care formulations and suspensions are provided. Uncoated calcium silicate exhibits a high pH level that may have a deleterious effect upon such cosmetic and/or personal care compositions, thereby rendering the overall composition ineffective for its intended purpose, particularly if the calcium silicate is present in its usual state at high loading levels. Alternatively, if certain materials present within personal care compositions exhibit a sufficiently low pH level, the effectiveness of such calcium silicates may be compromised as well. Such novel coated/treated calcium silicates thus permit high loadings of this beneficial odor neutralizing/sebum absorbing additive within cosmetic and/or personal care formulations without causing any appreciable instability issues or viscosity modification concerns or allow for coexistence with such low pH materials without any appreciable reduction in performance capabilities of the calcium silicates themselves. Certain personal care compositions comprising these novel coated calcium silicate particulates are encompassed within this invention as well.

  本发明提供了金属（例如钙）硅酸盐的涂覆颗粒，当存在于某些化妆品和/或个人护理配方和悬浮液中时，表现出优异的气味中和和皮脂吸收性能。未涂覆的硅酸钙表现出高pH值，可能对这些化妆品和/或个人护理组合物产生不良影响，从而使整个组合物对其预期用途无效，特别是如果硅酸钙以高负荷水平存在于其通常状态下。或者，如果某些材料在个人护理组合物中呈现出足够低的pH值，则这些硅酸钙的有效性也可能会受到影响。因此，这种新型涂覆/处理的硅酸钙允许在化妆品和/或个人护理配方中高负荷这种有益的气味中和/皮脂吸收添加剂，而不会引起任何明显的不稳定性问题或粘度修改问题，或者允许与这些低pH材料共存，而不会明显降低硅酸钙本身的性能能力。本发明还涵盖了包含这些新型涂覆硅酸钙颗粒的某些个人护理组合物。
• Hydrophobically coated/treated metal silicate abosrbent particles and personal care compositions thereof
  申请人：Withiam C. Michael

  公开号：US20070254039A1

  公开（公告）日：2007-11-01

  Coated particles of metal (such as calcium) silicate that exhibit excellent odor neutralization and sebum absorption properties when present within certain cosmetic and/or personal care formulations and suspensions are provided. Uncoated calcium silicate exhibits a high pH level that may have a deleterious effect upon such cosmetic and/or personal care compositions, thereby rendering the overall composition ineffective for its intended purpose, particularly if the calcium silicate is present in its usual state at high loading levels. Alternatively, if certain materials present within personal care compositions exhibit a sufficiently low pH level, the effectiveness of such calcium silicates may be compromised as well. Such novel coated/treated calcium silicates thus permit high loadings of this beneficial odor neutralizing/sebum absorbing additive within cosmetic and/or personal care formulations without causing any appreciable instability issues or viscosity modification concerns or allow for coexistence with such low pH materials without any appreciable reduction in performance capabilities of the calcium silicates themselves. Certain personal care compositions comprising these novel coated calcium silicate particulates are encompassed within this invention as well.

  本发明提供了金属（如钙）硅酸盐的涂层颗粒，当存在于某些化妆品和/或个人护理配方和悬浮液中时，表现出优异的气味中和和皮脂吸收性能。未涂层的硅酸钙表现出高pH值，可能对这些化妆品和/或个人护理组合物产生有害影响，从而使整体组合物对其预期用途无效，尤其是如果硅酸钙以高负载水平存在于其通常状态下。或者，如果个人护理组合物中存在某些材料具有足够低的pH值，则这些钙硅酸盐的有效性也可能受到损害。因此，这些新型涂层/处理的钙硅酸盐允许在化妆品和/或个人护理配方中高负载这种有益的气味中和/皮脂吸收添加剂，而不会引起任何明显的不稳定性问题或粘度修饰问题，或允许与这些低pH材料共存而不会显着降低钙硅酸盐本身的性能能力。本发明还涵盖了包括这些新型涂层钙硅酸盐颗粒的某些个人护理组合物。
• Exhaust gas treating agent, process for producing the same, and method of treating exhaust gas
  申请人：Sumitomo Osaka Cement Co., Ltd.

  公开号：US06676911B1

  公开（公告）日：2004-01-13

  The invention provides an exhaust gas treatment agent characterized in that it comprises calcium silicate hydrate particles having a mean particle diameter of 0.2 to 4 &mgr;m and a specific surface area of not less than 60 m2/g and calcium hydroxide particles having a mean particle diameter of not more than 4 &mgr;m and the content of calcium hydroxide particles in both particle components is within the range of 20 to 60% by weight; a method of producing the exhaust gas treatment agent; and a process for the treatment of exhaust gases and soot and dust which uses the exhaust gas treatment agent.

  本发明提供了一种废气处理剂，其特征在于包括平均粒径为0.2至4μm、比表面积不低于60m2/g的硅酸钙水合物颗粒和平均粒径不超过4μm的氢氧化钙颗粒，两种颗粒组分中氢氧化钙颗粒的含量在20至60%的重量范围内；一种生产废气处理剂的方法；以及使用废气处理剂进行废气、烟尘和灰尘处理的过程。
• Benzonatate modified release solid tablets and capsules
  申请人：TRIS Pharma Inc.

  公开号：US09180104B2

  公开（公告）日：2015-11-10

  A 12-hour anti-tussive modified release solid tablet or capsule is described which comprises a benzonatate in a matrix with a sufficient amount of one or more pharmaceutically acceptable modified release pH-independent, substances to provide a 12-hour modified release profile to the benzonatate, wherein there is substantially no benzonatate release from the tablet or capsule in the buccal cavity and no more than about 25% release of the benzonatate within 1 hour as determined in an in vitro dissolution assay. The modified release may be provided by (a) a high melt temperature, water-insoluble wax or waxy substance, (b) a low viscosity hydrophilic polymer such a hydroxypropyl methylcellulose, (c) a reverse enteric coating, or combinations thereof. The benzonatate may be in an adsorbate with a silico or silicate or in a complex with a weak acidic ion exchange resin complex.

  本发明涉及一种12小时抗咳改良释放固体片剂或胶囊，其包含苯佐卡因在基质中，与足够量的一种或多种药学上可接受的改良释放pH无关物质相结合，以提供苯佐卡因的12小时改良释放剖面，其中在颊囊腔内基本上没有苯佐卡因释放，并且在体外溶解试验中，在1小时内苯佐卡因的释放不超过大约25％。改良释放可以通过（a）高熔点温度，水不溶性蜡或蜡状物质，（b）低粘度亲水性聚合物，例如羟丙基甲基纤维素，（c）反向肠溶涂层或其组合来实现。苯佐卡因可以与硅或硅酸盐吸附物或弱酸性离子交换树脂复合物结合。