calcium;dinitrate

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱土金属氧阴离子化合物
• 英文名称: calcium;dinitrate
• 化学式: CaN2O6
• 分子量: 164.09
• InChiKey: ZCCIPPOKBCJFDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.86
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  126
• 氢给体数：
  0
• 氢受体数：
  6

ADMET

代谢

摄入一定量的硝酸盐和亚硝酸盐是人类氮循环的正常部分。在适当条件下，硝酸盐可以在胃肠道内转化为亚硝酸盐，显著增加硝酸盐的毒性。硝酸盐的主要代谢途径是转化为亚硝酸盐，然后转化为氨。亚硝酸盐、硝酸盐及其代谢物通过尿液排出体外。

Intake of some amount of nitrates and nitrites is a normal part of the nitrogen cycle in humans. In vivo conversion of nitrates to nitrites can occur in the gastrointestional tract under the right conditions, significantly enhancing nitrates' toxic potency. The major metabolic pathway for nitrate is conversion to nitrite, and then to ammonia. Nitrites, nitrates, and their metabolites are excreted in the urine. (L1137)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

硝酸盐的毒性是由于它进入体内后转化为亚硝酸盐。亚硝酸盐导致氧合血红蛋白自动催化氧化成过氧化氢和高铁血红蛋白。高铁血红蛋白水平的升高是一种称为高铁血红蛋白血症的条件，其特征是组织缺氧，因为高铁血红蛋白不能结合氧气。

Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

摄入硝酸盐或亚硝酸盐，在导致内源性亚硝化的条件下，对人类可能是致癌的（2A组）。

Ingested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A). (L135)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

硝酸盐和亚硝酸盐中毒会导致高铁血红蛋白血症。亚硝酸盐可能会导致怀孕并发症和发育影响。它们也可能具有致癌性。

Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

该物质可以通过吸入其气溶胶和通过摄入被身体吸收。

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 暴露途径

口服（L1137）；吸入（L1137）

Oral (L1137) ; inhalation (L1137)

来源:Toxin and Toxin Target Database (T3DB)

反应信息

• 作为反应物：
  描述：

  calcium;dinitrate 以97%的产率得到
  参考文献：
  名称：

  SAVOSKINA, A. I.;AFANASENKO, L. D.;TOPCHIJ, V. A.;AXKOZOV, E. A.;KRECHMER+, MATER. DLYA HOB. TEXN. (SINTEZ, TEXNOL. POLUCH., SVOJSTVA), M.,(1988) S. +

  摘要：

  DOI：
• 作为产物：
  描述：

  硝酸铵 生成 calcium;dinitrate
  参考文献：
  名称：

  MOROZOVA, G. A., ISSLED. V OBL. PR-BA UDOBR., L.,(1989) S. 81-92

  摘要：

  DOI：

文献信息

• Benzopyran-2-carboxylic acids in the prevention of asthmatic symptoms
  申请人：Fisons Limited

  公开号：US03952104A1

  公开（公告）日：1976-04-20

  There are described certain mono-chromone-2-carboxylic acids of formula, ##SPC1## Having one substituent in the 5 or 6 position or having 2 or more substituents in the 5,6,7 or 8 positions. There are also described processes for making the compounds and pharmacetuical compositions, for the treatment of asthma, containing the compounds.

  描述了一些具有以下公式的单色酮-2-羧酸，##SPC1## 在5或6位置有一个取代基或在5,6,7或8位置有2个或更多的取代基。还描述了制备这些化合物的过程和含有这些化合物的用于治疗哮喘的药物组合物。
• Inorganic shaped bodies and methods for their production and use
  申请人：——

  公开号：US20030175321A1

  公开（公告）日：2003-09-18

  Shaped, preferably porous, inorganic bodies are provided which are prepared from a reactive blend. In accordance with one preferred embodiment, the solution is absorbed into a porous sacrificial substrate such as a cellulose sponge. The solution-saturated substrate is heated and an oxidation-reduction reaction occurs thereby forming an inorganic solid. A shaped, inorganic body is formed in situ. Optional, but preferred additional thermal treatment of the shaped, inorganic body removes the organic substrate, leaving an inorganic body that faithfully mimics the porosity, shape, and other physical characteristics of the organic substrate. Inorganic substrates may also be used to good effect. Large varieties of shaped bodies can be prepared in accordance with other embodiments of the invention and such shapes find wide use in surgery, laboratory and industrial processes and otherwise. The invention also provides chemically and morphologically uniform powders, including those having uniformly small sizes.

  本发明提供了一种由反应性混合物制备的形状优选为多孔的无机体。根据一种优选实施例，该溶液被吸收到多孔的牺牲性基质中，例如纤维素海绵中。该溶液饱和的基质被加热，氧化还原反应发生，从而形成无机固体。在原位形成一个形状的无机体。可选的，但是优选的附加热处理形状的无机体去除有机基质，留下一个无机体，其忠实地模拟有机基质的多孔性、形状和其他物理特性。无机基质也可以被有效地使用。根据本发明的其他实施例可以制备大量形状的体，并且这些形状在外科手术、实验室和工业过程以及其他领域中得到广泛应用。本发明还提供了化学和形态均匀的粉末，包括具有均匀小尺寸的粉末。
• Scale inhibition
  申请人：FMC Corporation

  公开号：US05160630A1

  公开（公告）日：1992-11-03

  A method of inhibiting the precipitation of calcium carbonate scale from an aqueous system, comprising adding to the aqueous system, a compound having the formula I: ##STR1## in which M is hydrogen or an alkali metal ion, an ammonium ion or a quaternized amine radical; R.sub.1 is hydrogen or methyl; and n is an integer ranging from 1 to 10.

  一种抑制水系中碳酸钙沉淀的方法，包括向水系中添加具有以下式子I的化合物：##STR1## 其中M是氢或碱金属离子、铵离子或季铵基；R.sub.1是氢或甲基；n是1到10的整数。
• Process for preparing metal salts of alkyl phosphates
  申请人：Sakai Chemical Industry Company, Ltd.

  公开号：US04163018A1

  公开（公告）日：1979-07-31

  A process for preparing metal salts of alkyl phosphate of either one of the formulae: ##STR1## WHICH COMPRISES REACTING AN ALKYL PHOSPHATE OF EITHER ONE OF THE FORMULAE: ##STR2## in the form of its alkali metal salt with a metal salt of the formula: M.sub.n X.sub.m in an aqueous medium at a temperature of from about 50.degree. to 80.degree. C. (wherein R is an alkyl group of not less than 12 carbon atoms, M is an alkaline earth metal, aluminum or zinc, X is halogen ion, sulfate ion or nitrate ion, l is an integer corresonding to the atomic valency of M, r is an integer of 0, 1 or 2, m is an integer of 1, 2 or 3 and n is an integer of 1 or 2).

  制备烷基磷酸盐金属盐的方法，其包括在水介质中，将式之一的烷基磷酸盐以其碱金属盐的形式与式M.sub.nX.sub.m的金属盐反应，其中R是不少于12个碳原子的烷基，M是碱土金属、铝或锌，X是卤离子、硫酸根离子或硝酸根离子，l是M的原子价对应的整数，r是0、1或2的整数，m是1、2或3的整数，n是1或2的整数，反应温度在50℃到80℃之间。
• Reclamation process for water-borne uranium
  申请人：General Electric Company

  公开号：US04402918A1

  公开（公告）日：1983-09-06

  A process for treating water containing chemicals comprising ammonium nitrate, fluorides, hydrogen peroxide and uranium compounds, wherein valuable and/or hazardous components of the chemicals-containing water are separated therefrom and concentrated for recovery. The process includes an ion exchange operation in addition to manipulations of chemical components and pH conditions of the water by means of the application of reagents and adsorbents.

  一种处理含有硝酸铵、氟化物、过氧化氢和铀化合物的水的方法，其中将含有化学物质的水中的有价值和/或危险的成分与浓缩以便回收。该过程包括离子交换操作以及通过应用试剂和吸附剂对水的化学成分和pH条件进行操作。