1-Phenylacetyl-4-phenyl-piperidinol-(4) | 16334-11-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Phenylacetyl-4-phenyl-piperidinol-(4)
• 英文别名: 4-phenyl-1-phenylacetyl-piperidin-4-ol；1-(4-Hydroxy-4-phenylpiperidin-1-yl)-2-phenylethanone
• CAS: 16334-11-5
• 化学式: C₁₉H₂₁NO₂
• 分子量: 295.381
• InChiKey: GNNKLWVXZWILJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Antifouling Compounds And Use Thereof
  申请人：Teo Lay Ming Serena

  公开号：US20110092518A1

  公开（公告）日：2011-04-21

  The present invention relates to the use of compounds which have the following general formula (I), wherein R 1 and R 2 are independently selected from optionally substituted aryl, optionally substituted C 1 to C 12 alkyl and H; and R 3 and R 4 are independently selected from hydroxy, optionally substituted C 1 to C 6 alkyl, optionally substituted phenyl and H, in a method of preventing or reducing fouling, particularly in the marine environment. The compounds of the present invention have the considerable advantage of providing the antifouling coating market with an organic alternative to the existing technology which relies heavily on the addition of copper to obtain significant antifouling effects. The compounds we have developed may be used as cheap, easy to prepare additives that do not contain metals and therefore have reduced toxicity in marine environment.

  本发明涉及使用具有以下一般式(I)的化合物，其中R1和R2分别选自可选取代芳基、可选取代的C1到C12烷基和H；R3和R4分别选自羟基、可选取代的C1到C6烷基、可选取代的苯基和H，在防止或减少污垢，特别是在海洋环境中的方法中。本发明的化合物具有显著优势，为防污涂层市场提供了一种有机替代现有技术的选择，现有技术主要依赖于添加铜来获得显著的防污效果。我们开发的化合物可作为廉价、易于制备的添加剂使用，不含金属，因此在海洋环境中具有较低的毒性。
• [EN] ANTIFOULING COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS ANTISALISSURES ET LEUR UTILISATION
  申请人：UNIV SINGAPORE

  公开号：WO2009139729A1

  公开（公告）日：2009-11-19

  The present invention relates to the use of compounds which have the following general formula (I), wherein R1 and R2 are independently selected from optionally substituted aryl, optionally substituted C1 to C12 alkyl and H; and R3 and R4 are independently selected from hydroxy, optionally substituted C1 to C6 alkyl, optionally substituted phenyl and H, in a method of preventing or reducing fouling, particularly in the marine environment. The compounds of the present invention have the considerable advantage of providing the antifouling coating market with an organic alternative to the existing technology which relies heavily on the addition of copper to obtain significant antifouling effects. The compounds we have developed may be used as cheap, easy to prepare additives that do not contain metals and therefore have reduced toxicity in marine environment.