1-(1-(3,4-difluorobenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | 1207063-45-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(1-(3,4-difluorobenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
• 英文别名: 3-[1-[(3,4-difluorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one
• CAS: 1207063-45-3
• 化学式: C₁₉H₁₉F₂N₃O
• 分子量: 343.376
• InChiKey: OJWZJYMRLZOWHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 5HT7 receptor ligands and compositions comprising the same
  申请人：Laboratorios Del. Dr. Esteve, S.A.

  公开号：EP2149373A1

  公开（公告）日：2010-02-03

  The present invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, especially as agonists, identified by using a pharmacophore and a descriptor's profile filter as well as to pharmaceutical compositions comprising them. These compounds are useful in therapy in particular for the treatment and or prophylaxis of a disease in which 5-HT7 is involved, such as CNS disorders.

  本发明涉及具有药理活性的化合物，特别是作为5-HT7受体激动剂，通过使用药效团和描述符的配置文件筛选识别，以及包含它们的药物组合物。这些化合物在治疗中特别有用，特别是用于治疗和/或预防涉及5-HT7的疾病，如中枢神经系统紊乱。
• Method for screening of 5HT7 receptor ligands based on a new pharmacophore model and a descriptor's profile filter
  申请人：Laboratorios Del. Dr. Esteve, S.A.

  公开号：EP2151777A1

  公开（公告）日：2010-02-10

  The present invention relates to compounds having pharmacological activity towards the 5-HT7 receptor; to a method for identifying them as 5-HT7 ligands, especially as agonists, by using a pharmacophore and a descriptor's profile filter; to pharmaceutical compositions comprising them; and to their use in therapy, in particular for the treatment and or prophylaxis of a disease in which 5-HT7 is involved, such as CNS disorders.

  本发明涉及对5-HT7受体具有药理活性的化合物；涉及通过使用药效谱和描述符特征过滤器将它们鉴定为5-HT7配体，特别是激动剂的方法；涉及包含它们的药物组合物；涉及它们在治疗中的用途，特别是用于治疗和预防5-HT7参与的疾病，如中枢神经系统疾病。
• METHOD FOR SCREENING OF 5HT7 RECEPTOR LIGANDS BASED ON A NEW PHARMACOPHORE MODEL AND A DESCRIPTOR'S PROFILE FILTER
  申请人：Laboratorios del. Dr. Esteve, S.A.

  公开号：EP2310973A2

  公开（公告）日：2011-04-20
• 5HT7 RECEPTOR LIGANDS AND COMPOSITIONS COMPRISING THE SAME
  申请人：Laboratorios del. Dr. Esteve, S.A.

  公开号：EP2344162A2

  公开（公告）日：2011-07-20
• [EN] 5HT7 RECEPTOR LIGANDS AND COMPOSITIONS COMPRISING THE SAME<br/>[FR] LIGANDS DU RÉCEPTEUR 5-HT7 ET COMPOSITIONS LES CONTENANT
  申请人：ESTEVE LABOR DR

  公开号：WO2010012817A2

  公开（公告）日：2010-02-04

  The present invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, especially as agonists, identified by using a pharmacophore and a descriptor's profile filter as well as to pharmaceutical compositions comprising them. These compounds are useful in therapy in particular for the treatment and or prophylaxis of a disease in which 5-HT7 is involved, such as CNS disorders.