3-Azabicyclo<5.4.0>undecan | 94168-09-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-Azabicyclo<5.4.0>undecan
• 英文别名: 2,3,4,5,5a,6,7,8,9,9a-decahydro-1H-benzo[c]azepine
• CAS: 94168-09-9
• 化学式: C₁₀H₁₉N
• 分子量: 153.268
• InChiKey: CYDCIIRMKHJOAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• PYRROLOPYRIMIDINE DERIVATIVE
  申请人：TEIJIN LIMITED

  公开号：EP1477490A1

  公开（公告）日：2004-11-17

  A pyrrolo[3,2-d]pyrimidine derivative represented by the formula (I) or a pharamaceutically acceptable salt of the derivative. The derivative or salt is useful as a GSK-3 inhibitor.

  由式（I）代表的吡咯并[3,2-d]嘧啶衍生物或该衍生物的法学上可接受的盐。该衍生物或盐可用作 GSK-3 抑制剂。
• PROCESSES FOR THE PREPARATION OF BENZOTRIAZOLE UV ABSORBERS
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1305298A2

  公开（公告）日：2003-05-02
• TGFßR1 INHIBITOR-ASGR ANTIBODY CONJUGATES AND USES THEREOF
  申请人：Silverback Therapeutics, Inc.

  公开号：US20210130473A1

  公开（公告）日：2021-05-06

  Various conjugates and compositions thereof are disclosed for use in the treatment of a liver disease, such as liver cancer and liver fibrosis. The compositions comprise conjugates, wherein the conjugates are comprised of an antibody or antibody construct specific for ASGR1 or ASGR2 attached to a TGFβR1 inhibitor via a linker. Additionally provided are the methods of preparation of the conjugates and compositions thereof.
• US4141894A
  申请人：——

  公开号：US4141894A

  公开（公告）日：1979-02-27
• [EN] PROCESSES FOR THE PREPARATION OF BENZOTRIAZOLE UV ABSORBERS<br/>[FR] PROCEDE DE PREPARATION D'ABSORBEURS D'UV BENZOTRIAZOLES
  申请人：CIBA SC HOLDING AG

  公开号：WO2002012202A2

  公开（公告）日：2002-02-14

  Provided is a process for preparing 2H-benzotriazole UV absorbers containing a perfluoroalkyl moiety at the 5-position of the benzo ring, for example a trifluoromethyl group, which involves diazotizing the perfluoroalkyl substituted o-nitroaniline using concentrated sulfuric acid plus sodium nitrite or nitrosylsulfuric acid to form the corresponding monoazobenzene intermediate via the diazonium salt intermediate which is reduced to the corresponding 5-perfluoroalkyl substituted 2H-benzotriazole UV absorber compound by conventional reduction means. Also provided is a novel one-pot, multiphase reaction for the preparation of 2(2-nitrophenylazo) substituted phenols, which are precursors for 2H-benzotriazole UV absorbers.