2-Trimethylsilylsulfanylethyl 2-methylprop-2-enoate | 214832-74-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 2-Trimethylsilylsulfanylethyl 2-methylprop-2-enoate
• CAS: 214832-74-3
• 化学式: C₉H₁₈O₂SSi
• 分子量: 218.392
• InChiKey: HIAONALAYIMIQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.67
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  <2-(trimethylsiloxy)ethylthio>trimethylsilane 、 甲基丙烯酰氯 以 二氯甲烷 为溶剂， 反应 6.0h， 以18%的产率得到2-Trimethylsilylsulfanylethyl 2-methylprop-2-enoate
  参考文献：
  名称：

  A new strategy for chemoselective O-acylation of β-mercapto alcohols via alkylsilyl and stannyl protection

  摘要：

  Chemoselective preparation of O-acylated derivatives from bis-protected mercapto alcohols was described. Trialkylsilyl and trialkylstannyl chloride are used to generate an intermediate with O- and S-protection. The intermediates from beta-mercapto alcohols are reactive toward acylating agents and selective to provide O-acylated derivatives. The present preparation involves the direct conversion of alcohol to the corresponding O-acylated compounds without deprotection. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.11.047

文献信息

• A new strategy for chemoselective O-acylation of β-mercapto alcohols via alkylsilyl and stannyl protection
  作者：Muchchintala Maheswara、Mirae Kim、Sun-Ju Yun、Jung Jin Ju、Jung Yun Do

  DOI：10.1016/j.tetlet.2008.11.047

  日期：2009.1

  Chemoselective preparation of O-acylated derivatives from bis-protected mercapto alcohols was described. Trialkylsilyl and trialkylstannyl chloride are used to generate an intermediate with O- and S-protection. The intermediates from beta-mercapto alcohols are reactive toward acylating agents and selective to provide O-acylated derivatives. The present preparation involves the direct conversion of alcohol to the corresponding O-acylated compounds without deprotection. (C) 2008 Elsevier Ltd. All rights reserved.