3-[Methyl(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]propanenitrile | 113969-29-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶二唑类
• 英文名称: 3-[Methyl(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]propanenitrile
• 英文别名: 3-[methyl-(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]propanenitrile
• CAS: 113969-29-2
• 化学式: C10H9N5O3
• 分子量: 247.21
• InChiKey: YWZIRJRFBNJTNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  112
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• MOLECULAR MODULE
  申请人：The University of Tokyo

  公开号：EP2098538A1

  公开（公告）日：2009-09-09

  The present invention aims at providing a general-purpose experimental tool which specifically binds to a macromolecular substance that will be a receptor for a specific ligand such as drug, and is applicable throughout various processes to explore the nature of the macromolecular substance. In order to achieve this object, a molecular module has been developed which binds to a target compound and is used for purifying or labeling the target compound, wherein the molecular module has a rod-like spacer substance, an interacting substance that interacts with the target compound, a tag and a labeling substance, the interacting substance being positioned at one end of the rod-like spacer substance, and the tag and the labeling substance being positioned at the other end of the rod-like spacer substance.

  本发明的目的是提供一种通用的实验工具，它能专门与大分子物质结合，使其成为特定配体（如药物）的受体，并适用于探索大分子物质性质的各种过程。为了实现这一目标，我们开发了一种分子模块，它能与目标化合物结合，并用于纯化或标记目标化合物，其中分子模块具有杆状间隔物质、与目标化合物相互作用的相互作用物质、标签和标记物质，相互作用物质位于杆状间隔物质的一端，标签和标记物质位于杆状间隔物质的另一端。
• Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation
  申请人：Baker F. Brenda

  公开号：US20050037370A1

  公开（公告）日：2005-02-17

  Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers has a modified base for binding to an adenine or guanine base in the opposite strand. Oligonucleotide/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein the oligomer has a modified base for binding to an adenine or guanine base in the opposite strand.

  提供了包含第一和第二寡聚体的寡聚体组合物，其中第一寡聚体的至少一部分能够与第二寡聚体的至少一部分杂交，第一寡聚体的至少一部分与所选靶核酸互补并能够与所选靶核酸杂交，第一或第二寡聚体的至少一种具有修饰碱基，用于与相反链中的腺嘌呤或鸟嘌呤碱基结合。还提供了寡核苷酸/蛋白质组合物，该组合物包含与所选靶核酸互补并能与之杂交的寡聚体，以及至少一种包含 RNA 诱导沉默复合体（RISC）至少一部分的蛋白质，其中寡聚体具有与相反链中腺嘌呤或鸟嘌呤碱基结合的修饰碱基。
• US5677440A
  申请人：——

  公开号：US5677440A

  公开（公告）日：1997-10-14
• US8304520B2
  申请人：——

  公开号：US8304520B2

  公开（公告）日：2012-11-06